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Doxapram hydrochloride hydrate

🥰Excellent
Catalog No. T0038Cas No. 7081-53-0
Alias Doxapram hydrochloride monohydrate, Doxapram HCl

Doxapram hydrochloride hydrate (Doxapram HCl) effectively inhibits the function of TASK-1, TASK-3, and TASK-1/TASK-3 heterodimeric channels, displaying EC50 values of 410 nM, 37 μM, and 9 μM, respectively.

Doxapram hydrochloride hydrate
Other Forms of Doxapram hydrochloride hydrate:
DoxapramT22315309-29-5
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Doxapram hydrochloride hydrate

🥰Excellent
Purity: 99.64%
Catalog No. T0038Alias Doxapram hydrochloride monohydrate, Doxapram HClCas No. 7081-53-0
Doxapram hydrochloride hydrate (Doxapram HCl) effectively inhibits the function of TASK-1, TASK-3, and TASK-1/TASK-3 heterodimeric channels, displaying EC50 values of 410 nM, 37 μM, and 9 μM, respectively.
Pack SizePriceAvailabilityQuantity
25 mg$35In Stock
50 mg$52In Stock
100 mg$81In Stock
200 mg$118In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Batch Information

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Purity:99.64%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Doxapram hydrochloride hydrate (Doxapram HCl) effectively inhibits the function of TASK-1, TASK-3, and TASK-1/TASK-3 heterodimeric channels, displaying EC50 values of 410 nM, 37 μM, and 9 μM, respectively.
Targets&IC50
TASK1 (heterodimeric channel):9 μM(EC50), TASK1:410 nM(EC50), TASK3:37 μM(EC50)
SynonymsDoxapram hydrochloride monohydrate, Doxapram HCl
Chemical Properties
Molecular Weight432.99
FormulaC24H33ClN2O3（C24H30N2O2·ClH·H2O）
Cas No.7081-53-0
SmilesCl.CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 81 mg/mL (187.07 mM), Sonication is recommended.
Ethanol: 2 mg/mL (4.62 mM), Sonication is recommended.
H2O: 23 mg/mL (53.12 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/H2O/DMSO
1mg5mg10mg50mg
1 mM2.3095 mL11.5476 mL23.0952 mL115.4761 mL
H2O/DMSO
1mg5mg10mg50mg
5 mM0.4619 mL2.3095 mL4.6190 mL23.0952 mL
10 mM0.2310 mL1.1548 mL2.3095 mL11.5476 mL
20 mM0.1155 mL0.5774 mL1.1548 mL5.7738 mL
50 mM0.0462 mL0.2310 mL0.4619 mL2.3095 mL
DMSO
1mg5mg10mg50mg
100 mM0.0231 mL0.1155 mL0.2310 mL1.1548 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TASK-3TASK-1/TASK-3 heterodimericTASK-1PotassiumChannelPotassium ChannelKcsAInhibitorinhibitDoxapram hydrochloride MonohydrateDoxapram hydrochloride HydrateDoxapram hydrochloride hydrateDoxapram HydrochlorideDoxapram hydrochloride
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