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Anti-IL-6R Antibody-APC (5X839)
🥰Excellent
Catalog No. TMAY-03209A
Anti-IL-6R Antibody-APC (5X839) is a APC-conjugated Rabbit antibody targeting IL-6R. Anti-IL-6R Antibody-APC (5X839) can be used in FCM.
Anti-IL-6R Antibody-APC (5X839)
Anti-IL-6R Antibody-APC (5X839)
🥰Excellent
Catalog No. TMAY-03209A
Anti-IL-6R Antibody-APC (5X839) is a APC-conjugated Rabbit antibody targeting IL-6R. Anti-IL-6R Antibody-APC (5X839) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL-6R Antibody-APC (5X839) is a APC-conjugated Rabbit antibody targeting IL-6R. Anti-IL-6R Antibody-APC (5X839) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5X839 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse IL-6R expression on BABL/c splenocytes. Cells were stained with APC-conjugated anti-Human Mouse IL-6R. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-6R / CD126 (rM IL-6R / CD126; TMPY-01214; NP_034689.2; Ile44-Glu357) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | APC |
| Others Formats | Unconjugated/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Mouse IL-6R / CD126 protein (TMPY-01214) |
| Antigen Species | Mouse |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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