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Anti-RPE65 Antibody (7P282)

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Catalog No. TMAB-12352

Anti-RPE65 Antibody (7P282) is a Rabbit antibody targeting RPE65. Anti-RPE65 Antibody (7P282) can be used in WB,IP,IHC-P,IHC-Fr,IF.

Anti-RPE65 Antibody (7P282)

Anti-RPE65 Antibody (7P282)

😃Good
Catalog No. TMAB-12352
Anti-RPE65 Antibody (7P282) is a Rabbit antibody targeting RPE65. Anti-RPE65 Antibody (7P282) can be used in WB,IP,IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1517-10 days7-10 days
50 μL$2637-10 days7-10 days
100 μL$4717-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-RPE65 Antibody (7P282) is a Rabbit antibody targeting RPE65. Anti-RPE65 Antibody (7P282) can be used in WB,IP,IHC-P,IHC-Fr,IF.
Ig Type
IgG
Clone
7P282
Reactivity
Mouse,Rat (predicted:Human)
Application
WB
IP
IHC-P
IHC-Fr
IF
Recommended Dose
WB: 1:500-2000; IP: 1:20-50; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Cell membrane. Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated.
Tissue SpecificityRetinal pigment epithelium specific.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundCritical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore
Antigen Details
Immunogen
A synthesized peptide: human RPE65
Antigen Species
Human
Gene Name
RPE65
Gene ID
6121
Protein Name
Retinoid isomerohydrolase
Uniprot ID
Q16518
Function
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.
Chemical Properties
Molecular WeightTheoretical: 61 kDa. Actual: 61 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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