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Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850)
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Catalog No. TMAY-00302F
Alias interleukin 1 receptor accessory protein
Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) is a FITC-conjugated Mouse antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) can be used in FCM.
Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850)
Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850)
😃Good
Catalog No. TMAY-00302FAlias interleukin 1 receptor accessory protein
Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) is a FITC-conjugated Mouse antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 T | $104 | 7-10 days | |
| 100 T | $210 | 7-10 days |
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Chemical Properties
| Description | Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) is a FITC-conjugated Mouse antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody-FITC (2C850) can be used in FCM. |
| Alias | interleukin 1 receptor accessory protein |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 2C850 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of anti-human IL1R3 on human whole blood monocytes. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable monocytes. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-1RAcP / IL-1R3 (rh IL-1RAcP / IL-1R3; TMPY-01251; NP_002173.1; Met 1-Glu 359) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.1% sodium azide |
| Research Background | Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces the synthesis of the acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signaling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor. |
| Conjucates | FITC |
| Others Formats | Unconjugated/APC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human IL-1RAcP / IL-1R3 protein (TMPY-01251) |
| Antigen Species | Human |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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