Shopping Cart

Your shopping cart is currently empty

DZ2002

Name: DZ2002
Brand: TargetMol
SKU: T11134
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T11134Cas No. 33231-14-0

DZ2002, an orally active, reversible, and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), exhibits significant immunosuppressive activity. It effectively prevents experimental dermal fibrosis by reversing the profibrotic phenotype in multiple cell types, making it useful for studying autoimmune diseases like lupus syndrome and systemic sclerosis.

DZ2002

😃Good

Purity: 99.91%

Catalog No. T11134Cas No. 33231-14-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	In Stock	In Stock
5 mg	$278	In Stock	In Stock
10 mg	$413	In Stock	In Stock
25 mg	$678	In Stock	In Stock
50 mg	$953	In Stock	In Stock
100 mg	$1,280	-	In Stock
500 mg	$2,570	-	In Stock
1 mL x 10 mM (in DMSO)	$297	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	DZ2002, an orally active, reversible, and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), exhibits significant immunosuppressive activity. It effectively prevents experimental dermal fibrosis by reversing the profibrotic phenotype in multiple cell types, making it useful for studying autoimmune diseases like lupus syndrome and systemic sclerosis.
In vitro	DZ2002 (0.1, 1, 10 µM; 96 h) inhibits the mixed lymphocyte reaction (MLR) response, IL-12 and TNF-α production from both mouse peritoneal exudate cells and human THP-1 cells (24 h), and expression of B7 (CD80/CD86) on differentiated THP-1 cells (64 h) [1].
In vivo	DZ2002 (2, 10, 50 mg/kg; i.p.; twice) blocks the DNFB-induced DTH response—a Th1 cell-mediated immune response with high IL-12 expression and significant macrophage involvement. DZ2002 (0.08, 2 mg/kg; i.p.; daily for 7 days) significantly suppresses delayed-type hypersensitivity and antibody secretion[1]. DZ2002 (50, 100 mg/kg; p.o.; daily for 4 weeks) exhibits a potent anti-fibrotic effect on dermal fibrosis by reducing collagen production, enhancing its degradation, and regulating various soluble factors in SSc mice model[2].

Chemical Properties

Molecular Weight	251.24
Formula	C₁₀H₁₃N₅O₃
Cas No.	33231-14-0
Smiles	COC(=O)C(O)CCn1cnc2c(N)ncnc12
Relative Density.	1.58 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (179.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9803 mL	19.9013 mL	39.8026 mL	199.0129 mL
5 mM	0.7961 mL	3.9803 mL	7.9605 mL	39.8026 mL
10 mM	0.3980 mL	1.9901 mL	3.9803 mL	19.9013 mL
20 mM	0.1990 mL	0.9951 mL	1.9901 mL	9.9506 mL
50 mM	0.0796 mL	0.3980 mL	0.7961 mL	3.9803 mL
100 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9901 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc