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Skullcapflavone II

Name: Skullcapflavone II
Brand: TargetMol
SKU: TN1040
Price: 85 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1040Cas No. 55084-08-7

Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of allergic asthma.Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG

Skullcapflavone II

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Purity: 99.89%

Catalog No. TN1040Cas No. 55084-08-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$85	In Stock	In Stock
5 mg	$172	In Stock	In Stock
10 mg	$259	In Stock	In Stock
25 mg	$519	In Stock	In Stock
50 mg	$743	-	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Skullcapflavone II AI Summary

Skullcapflavone II shows binding affinity to the GABAA receptor with a logKi value of -0.444, indicating potential bioactivity related to neurotransmission regulation and therapeutic interventions for anxiety and epilepsy. It inhibits trypsin-induced elevation of plasminogen activator inhibitor 1 (PAI1) production in human umbilical vein endothelial cells with an IC50 value of 110,000 nM, as measured by ELISA. In the NCI human tumor cell line growth inhibition assay, it displays growth inhibition across various cancer cell lines, with GI50 values ranging from approximately 4,800 nM to 50,900 nM, suggesting potential anti-cancer properties against diverse cancer types. Additionally, Skullcapflavone II inhibits Avian myeloblastosis virus reverse transcriptase with an inhibition rate of 18.0% and reduces PCSK9 mRNA expression by 42.4% in human HepG2 cells at 20 μM after 24 hours, as determined by qRT-PCR analysis..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	374.34
Formula	C₁₉H₁₈O₈
Cas No.	55084-08-7
Smiles	COc1cccc(O)c1-c1cc(=O)c2c(O)c(OC)c(OC)c(OC)c2o1
Relative Density.	1.375 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (133.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6714 mL	13.3568 mL	26.7137 mL	133.5684 mL
5 mM	0.5343 mL	2.6714 mL	5.3427 mL	26.7137 mL
10 mM	0.2671 mL	1.3357 mL	2.6714 mL	13.3568 mL
20 mM	0.1336 mL	0.6678 mL	1.3357 mL	6.6784 mL
50 mM	0.0534 mL	0.2671 mL	0.5343 mL	2.6714 mL
100 mM	0.0267 mL	0.1336 mL	0.2671 mL	1.3357 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc