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PW0787

Name: PW0787
Brand: TargetMol
SKU: T9452
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9452Cas No. 2624131-45-7

PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM).

PW0787

🥰Excellent

Purity: 98.42%

Catalog No. T9452Cas No. 2624131-45-7

PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM).

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$73	In Stock
10 mg	$119	In Stock
25 mg	$248	In Stock
50 mg	$371	In Stock
100 mg	$527	In Stock
200 mg	$726	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock

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Batch Information

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Purity:98.42%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM).
Targets&IC50	GPR52:135 nM(EC50)

Chemical Properties

Molecular Weight	460.42
Formula	C₂₃H₂₀F₄N₄O₂
Cas No.	2624131-45-7
Smiles	OCCNC(=O)c1cccc2N(CCc12)c1cc(Cc2cc(F)cc(c2)C(F)(F)F)ncn1
Relative Density.	1.388 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (141.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1719 mL	10.8596 mL	21.7193 mL	108.5965 mL
5 mM	0.4344 mL	2.1719 mL	4.3439 mL	21.7193 mL
10 mM	0.2172 mL	1.0860 mL	2.1719 mL	10.8596 mL
20 mM	0.1086 mL	0.5430 mL	1.0860 mL	5.4298 mL
50 mM	0.0434 mL	0.2172 mL	0.4344 mL	2.1719 mL
100 mM	0.0217 mL	0.1086 mL	0.2172 mL	1.0860 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc