Shopping Cart

Your shopping cart is currently empty

PW0787

Name: PW0787
Brand: TargetMol
SKU: T9452
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T9452Cas No. 2624131-45-7

PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM).

PW0787

Copy Product Info

🥰Excellent

Purity: 98.42%

Catalog No. T9452Cas No. 2624131-45-7

PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$119	In Stock	In Stock
25 mg	$248	In Stock	In Stock
50 mg	$371	In Stock	In Stock
100 mg	$527	In Stock	In Stock
200 mg	$726	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.42%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

PW0787 AI Summary

PW0787 exhibits significant bioactivity as an agonist at the human GPR52 receptor, leading to increased cAMP levels with an Emax of 136.0% and an EC50 of 135.0 nM. Additionally, it inhibits ligand binding at various receptor sites including multiple serotonin receptors (5-HT1D, 5-HT1B, 5-HT2A, 5-HT1E, 5-HT1A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6, 5-HT7A), adrenergic receptors (alpha1A, beta1), dopamine receptors (DRD1, DRD3, DRD4), the dopamine transporter (DAT), GABAA, histamine receptors (HRH1, HRH2), the mu-opioid receptor (MOR), and muscarinic receptors (M3, M4), among others. In pharmacokinetic studies conducted in Sprague-Dawley rats, the compound shows notable metrics such as area under the curve (AUC), terminal half-life, maximum concentration (Cmax), clearance, volume of distribution, oral bioavailability, and drug uptake in both brain and plasma..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM).
Targets&IC50	GPR52:135 nM(EC50)

Chemical Properties

Molecular Weight	460.42
Formula	C₂₃H₂₀F₄N₄O₂
Cas No.	2624131-45-7
Smiles	OCCNC(=O)c1cccc2N(CCc12)c1cc(Cc2cc(F)cc(c2)C(F)(F)F)ncn1
Relative Density.	1.388 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (141.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1719 mL	10.8596 mL	21.7193 mL	108.5965 mL
5 mM	0.4344 mL	2.1719 mL	4.3439 mL	21.7193 mL
10 mM	0.2172 mL	1.0860 mL	2.1719 mL	10.8596 mL
20 mM	0.1086 mL	0.5430 mL	1.0860 mL	5.4298 mL
50 mM	0.0434 mL	0.2172 mL	0.4344 mL	2.1719 mL
100 mM	0.0217 mL	0.1086 mL	0.2172 mL	1.0860 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc