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MS0124
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Catalog No. T28112Cas No. 1197196-63-6
Alias MS-0124, MS 0124
MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
MS0124
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Purity: 98.97%
Catalog No. T28112Alias MS-0124, MS 0124Cas No. 1197196-63-6
MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | In Stock | In Stock | |
| 5 mg | $123 | In Stock | In Stock | |
| 10 mg | $206 | In Stock | In Stock | |
| 25 mg | $413 | In Stock | In Stock | |
| 50 mg | $662 | In Stock | In Stock | |
| 100 mg | $926 | - | In Stock | |
| 200 mg | $1,230 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $129 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.97%
Appearance:Solid
Color:White
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Product Introduction
MS0124 AI Summary
MS0124 demonstrates bioactivity as an inhibitor of the G9a enzyme, with IC50 values of 1600.0 nM in the Thioglo assay and 810.0 nM in the Alpha screen assay. It also inhibits the methyl transferase activity of G9a with IC50 values of 1600000.0 nM in the enzyme coupled S-adenosylhomocysteine detection assay and 810000.0 nM in the chemiluminescence-based oxygen tunneling assay. Moreover, MS0124 exhibits bioactivity in various assays targeting different biological processes, including human Flap endonuclease 1, mammalian selenoprotein thioredoxin reductase 1, human tyrosyl-DNA phosphodiesterase 1, and Stage-Specific Inhibitors of Vaccinia Orthopoxvirus, with potencies ranging from around 10,000 nM to 50,000 nM. Additionally, MS0124 inhibits the methylation activity of both recombinant G9a and GLP catalytic SET domains, showing higher potency for GLP with an IC50 of 13.0 nM compared to 440.0 nM for G9a. It displays a selectivity ratio favoring GLP over G9a and binds to both SET domains with a Kd of 40.0 nM for GLP and 445.0 nM for G9a, indicating a strong interaction with these proteins..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively. |
| Targets&IC50 | GLP:13 ± 4 nM, G9a:440 ± 63 nM |
| Synonyms | MS-0124, MS 0124 |
| Molecular Weight | 387.48 |
| Formula | C20H29N5O3 |
| Cas No. | 1197196-63-6 |
| Smiles | N(C=1C2=C(N=C(N1)N3CCOCC3)C=C(OC)C(OC)=C2)C4CCN(C)CC4 |
| Relative Density. | 1.232 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.88 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.58 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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