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AMG-966

Name: AMG-966
Brand: TargetMol
SKU: T9901A-1095
Rating: 4.5 (1 reviews)

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Catalog No. T9901A-1095

AMG-966 is a human bispecific antibody (bsAb) that targets TNFSF15/TL1A and TNFα. AMG-966 can restore the ability of the aglycosylated Fc domain to bind FcγRIa and FcγRIIa, which leads to the formation of antidrug antibodies (ADA). It is applicable for research in Crohn's disease and ulcerative colitis. Recommended isotype control: HumanIgG1kappa, Isotype Control.

AMG-966

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Catalog No. T9901A-1095

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	Inquiry	Inquiry	Inquiry
5 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Instruction Manual of Inhibitory Antibody

Product Introduction

Bioactivity

Description	AMG-966 is a human bispecific antibody (bsAb) that targets TNFSF15/TL1A and TNFα. AMG-966 can restore the ability of the aglycosylated Fc domain to bind FcγRIa and FcγRIIa, which leads to the formation of antidrug antibodies (ADA). It is applicable for research in Crohn's disease and ulcerative colitis. Recommended isotype control: HumanIgG1kappa, Isotype Control.
Reactivity	Human
Application	ELISA FACS Functional assay
Antibody Type	Monoclonal
Endotoxin	＜ 1.0 EU/mg

Related Conjugates and Formulations

Conjucates

Unconjugated

Chemical Properties

Storage & Solubility Information

Storage

store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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