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JGB1741

Catalog No. T22094 CAS 1256375-38-8

Synonyms: ILS-JGB-1741

JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/<a href="/target/BCL" style="display: inline; color: #c13a36">BCL</a>2 ratio, cytochrome c release and <a href="/target/PARP" style="display: inline; color: #c13a36">PARP</a> cleavage and increases the acetylated <a href="/target/p53" style="display: inline; color: #c13a36">p53</a> levels leading to <a href="/target/p53" style="display: inline; color: #c13a36">p53</a>-mediated <a href="/pathway/Apoptosis" style="display: inline; color: #c13a36">Apoptosis</a>. JGB1741 can be used in studies about breast cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

JGB1741, CAS 1256375-38-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 66.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 343.00
25 mg	In stock	$ 679.00
50 mg	In stock	$ 995.00
100 mg	In stock	$ 1,715.00

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Purity: 97.24%

Biological Description

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Storage & Solubility Information

Description	JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-mediated apoptosis. JGB1741 can be used in studies about breast cancer.
In vitro	JGB1741 (1-10000 nM) inhibits the cell proliferation of K562, HepG2 and MDA-MB 231 cell lines. JGB1741 (0.01-1 μM) induces apoptosis of MDA-MB 231 and shows a cell cycle arrest at G1 phase with more cells entering into sub G0/G1 phase. JGB1741 (0.01-1 μM) increases the global acetylation of H3K9, acetylated p53K382 levels and p53 expression[1].

Synonyms	ILS-JGB-1741
Molecular Weight	440.56
Formula	C27H24N2O2S
CAS No.	1256375-38-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Arunasree M Kalle, et al. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010 Oct 8;401(1):13-9.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Anti-Cancer Compound Library Epigenetics Compound Library Inhibitor Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

N-Caffeoyltryptophan (+)-Syringaresinol 5-Feruloylquinic acid MC2184 CAY10602 SIRT7 inhibitor 97491 Tenovin-6 SRT 2183

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JGB1741 1256375-38-8 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin ILS-JGB-1741 Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.