Powder: -20°C for 3 years
In solvent: -80°C for 2 years
JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/<a href="/target/BCL" style="display: inline; color: #c13a36">BCL</a>2 ratio, cytochrome c release and <a href="/target/PARP" style="display: inline; color: #c13a36">PARP</a> cleavage and increases the acetylated <a href="/target/p53" style="display: inline; color: #c13a36">p53</a> levels leading to <a href="/target/p53" style="display: inline; color: #c13a36">p53</a>-mediated <a href="/pathway/Apoptosis" style="display: inline; color: #c13a36">Apoptosis</a>. JGB1741 can be used in studies about breast cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 66.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 343.00 | |
25 mg | In stock | $ 679.00 | |
50 mg | In stock | $ 995.00 | |
100 mg | In stock | $ 1,715.00 |
Description | JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-mediated apoptosis. JGB1741 can be used in studies about breast cancer. |
In vitro | JGB1741 (1-10000 nM) inhibits the cell proliferation of K562, HepG2 and MDA-MB 231 cell lines. JGB1741 (0.01-1 μM) induces apoptosis of MDA-MB 231 and shows a cell cycle arrest at G1 phase with more cells entering into sub G0/G1 phase. JGB1741 (0.01-1 μM) increases the global acetylation of H3K9, acetylated p53K382 levels and p53 expression[1]. |
Synonyms | ILS-JGB-1741 |
Molecular Weight | 440.56 |
Formula | C27H24N2O2S |
CAS No. | 1256375-38-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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JGB1741 1256375-38-8 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin ILS-JGB-1741 Inhibitor inhibitor inhibit