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Corylifol A

Name: Corylifol A
Brand: TargetMol
SKU: T4S0145
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4S0145Cas No. 775351-88-7

Alias Corylinin

1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.

Corylifol A

🥰Excellent

Purity: 99.5%

Catalog No. T4S0145Alias CorylininCas No. 775351-88-7

Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$97	In Stock
10 mg	$155	In Stock
25 mg	$262	In Stock
50 mg	$389	In Stock
100 mg	$573	In Stock
500 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$148	In Stock

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Purity:99.5%

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COA LCMS LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. 3. Corylifol A and bavachin are strong inhibitors of UDP-glucuronosyltransferase 1A1 (UGT1A1) with the inhibition kinetic parameters (Ki) values lower than 1 uM.4. Corylifol A and bakuchiol are naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62uM to 3.89 uM. 5. Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uμ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells, suggests that corylifol A has antiinflammatory activity.
Targets&IC50	STAT3:0.81 μM
Synonyms	Corylinin

Chemical Properties

Molecular Weight	390.47
Formula	C₂₅H₂₆O₄
Cas No.	775351-88-7
Smiles	CC(C)=CCC\C(C)=C\Cc1cc(ccc1O)-c1coc2cc(O)ccc2c1=O
Relative Density.	1.191 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (128.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5610 mL	12.8051 mL	25.6102 mL	128.0508 mL
5 mM	0.5122 mL	2.5610 mL	5.1220 mL	25.6102 mL
10 mM	0.2561 mL	1.2805 mL	2.5610 mL	12.8051 mL
20 mM	0.1281 mL	0.6403 mL	1.2805 mL	6.4025 mL
50 mM	0.0512 mL	0.2561 mL	0.5122 mL	2.5610 mL
100 mM	0.0256 mL	0.1281 mL	0.2561 mL	1.2805 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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