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GSK547

Name: GSK547
Brand: TargetMol
SKU: T7397
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7397Cas No. 2226735-55-1

Alias GSK'547

GSK547 (GSK'547) is a highly selective and potent RIP1 kinase inhibitor that disrupts macrophage-mediated adaptive immune tolerance in pancreatic cancer.

GSK547

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Purity: 99.17%

Catalog No. T7397Alias GSK'547Cas No. 2226735-55-1

GSK547 (GSK'547) is a highly selective and potent RIP1 kinase inhibitor that disrupts macrophage-mediated adaptive immune tolerance in pancreatic cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$172	In Stock	In Stock
50 mg	$273	In Stock	In Stock
100 mg	$373	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.17%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

GSK547 AI Summary

GSK547 is a potent inhibitor of RIP1 (Receptor-interacting serine/threonine-protein kinase 1), exhibiting a high binding affinity with an IC50 value of 10.0 nM as demonstrated by fluorescence polarization assay. The compound effectively inhibits RIP1 autophosphorylation and necroptosis induction in both human and mouse cells. It shows good oral bioavailability in rats and maintains prolonged plasma concentration above the IC90 level for RIP1 in mouse L929 cells, indicating potential in vivo efficacy. Furthermore, its pharmacokinetic profile is characterized by moderate to high clearance rates and favorable distribution properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	GSK547 (GSK'547) is a highly selective and potent RIP1 kinase inhibitor that disrupts macrophage-mediated adaptive immune tolerance in pancreatic cancer.
Synonyms	GSK'547

Chemical Properties

Molecular Weight	396.39
Formula	C₂₀H₁₈F₂N₆O
Cas No.	2226735-55-1
Smiles	Fc1cc(F)cc(c1)[C@@H]1CC=NN1C(=O)C1CCN(CC1)c1cc(ncn1)C#N
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (315.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5228 mL	12.6138 mL	25.2277 mL	126.1384 mL
5 mM	0.5046 mL	2.5228 mL	5.0455 mL	25.2277 mL
10 mM	0.2523 mL	1.2614 mL	2.5228 mL	12.6138 mL
20 mM	0.1261 mL	0.6307 mL	1.2614 mL	6.3069 mL
50 mM	0.0505 mL	0.2523 mL	0.5046 mL	2.5228 mL
100 mM	0.0252 mL	0.1261 mL	0.2523 mL	1.2614 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc