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N-Me-N-bis-PEG4

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Catalog No. T16237Cas No. 2055046-22-3

N-Me-N-bis-PEG4 is a PEG-based linker integral to PROTACs, facilitating the conjugation of two essential ligands that form PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

N-Me-N-bis-PEG4

N-Me-N-bis-PEG4

😃Good
Catalog No. T16237Cas No. 2055046-22-3
N-Me-N-bis-PEG4 is a PEG-based linker integral to PROTACs, facilitating the conjugation of two essential ligands that form PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$385 days5 days
5 mg$585 days5 days
10 mg$835 days5 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
N-Me-N-bis-PEG4 is a PEG-based linker integral to PROTACs, facilitating the conjugation of two essential ligands that form PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.
In vitro
PROTACs comprise two distinct ligands linked together; one binds to an E3 ubiquitin ligase, while the other targets the intended protein, utilizing the intracellular ubiquitin-proteasome system to selectively degrade the target proteins[1].
Chemical Properties
Molecular Weight383.48
FormulaC17H37NO8
Cas No.2055046-22-3
Relative Density.1.096 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

PEGsN-Me-N-bis-PEG-4N-Me-N-bis-PEG4NMeNbisPEG4N Me N bis PEG4
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