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HTHQ
🥰Excellent
Catalog No. T3647Cas No. 148081-72-5
Alias HX 1171, HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone), 1-O-hexyl-2,3,5-trimethylhydroquinone
HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)), a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals.
HTHQ
🥰Excellent
Purity: 99.81%
Catalog No. T3647Alias HX 1171, HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone), 1-O-hexyl-2,3,5-trimethylhydroquinoneCas No. 148081-72-5
HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)), a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $37 | In Stock | |
| 25 mg | $58 | In Stock | |
| 50 mg | $77 | In Stock | |
| 100 mg | $97 | In Stock | |
| 200 mg | $158 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $40 | In Stock |
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Purity:99.81%
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Product Introduction
Bioactivity
Chemical Properties
| Description | HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)), a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals. |
| In vitro | HTHQ has an anti-oxidative activity similar to D,L-alpha-tocopherol against lipid peroxidation in linolate micelles initiated by addition of Fe2+. The anti-lipid-peroxidation activity of HTHQ is higher 4.8-fold than that of D,L-alpha-tocopherol against the peroxidation in phosphatidylcholine liposomes initiated by addition of Fe2+. [1] The effects of 0.02% Glu-P-1 or 0.03% MeIQx on the number and area of foci is significantly reduced by 0.125% HTHQ. [2] |
| In vivo | Treatment with HTHQ potently inhibits PhIP-induced mammary carcinogenesis in female rats. Compared with DMN-induced hepatic fibrosis animals in the liver tissue, HTHQ reduced mRNA level of PDGF (Platelet-derived growth factor), α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β). In this study, we showed that HTHQ improves against DMN-induced liver fibrosis in male SD rats. |
| Synonyms | HX 1171, HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone), 1-O-hexyl-2,3,5-trimethylhydroquinone |
| Molecular Weight | 236.35 |
| Formula | C15H24O2 |
| Cas No. | 148081-72-5 |
| Smiles | CCCCCCOc1cc(C)c(O)c(C)c1C |
| Relative Density. | 0.971 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 43 mg/mL (181.93 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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