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hDHODH-IN-7

Name: hDHODH-IN-7
Brand: TargetMol
SKU: T11031
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11031Cas No. 1644156-41-1

Alias DHODH-IN-9

hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. hDHODH-IN-7 and pMIC50 of 7.4 have antiviral effects.

hDHODH-IN-7

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Purity: 99.87%

Catalog No. T11031Alias DHODH-IN-9Cas No. 1644156-41-1

hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. hDHODH-IN-7 and pMIC50 of 7.4 have antiviral effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
2 mg	$175	In Stock	In Stock
5 mg	$269	In Stock	In Stock
10 mg	$395	In Stock	In Stock
25 mg	$592	In Stock	In Stock
50 mg	$834	In Stock	In Stock
100 mg	$1,120	-	In Stock
500 mg	$2,260	-	In Stock
1 mL x 10 mM (in DMSO)	$280	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. hDHODH-IN-7 and pMIC50 of 7.4 have antiviral effects.
Targets&IC50	DHODH:pMIC50:7.4
In vitro	hDHODH-IN-7 is the corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. There is almost no change, and the antiviral mode of action of the analogs with 5-cyclopyridine reflects the antiviral effect of homologues with 5-ethylpyrimidinyl groups to some extent. hDHODH-IN-7 is a good antiviral agent for such analogs[1].
Synonyms	DHODH-IN-9

Chemical Properties

Molecular Weight	366.43
Formula	C₂₁H₂₃FN₄O
Cas No.	1644156-41-1
Smiles	C(C=1C(OC(C)C)=NN(C1C)C=2N=CC(=CN2)C3CC3)C4=C(F)C=CC=C4
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (136.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7290 mL	13.6452 mL	27.2903 mL	136.4517 mL
5 mM	0.5458 mL	2.7290 mL	5.4581 mL	27.2903 mL
10 mM	0.2729 mL	1.3645 mL	2.7290 mL	13.6452 mL
20 mM	0.1365 mL	0.6823 mL	1.3645 mL	6.8226 mL
50 mM	0.0546 mL	0.2729 mL	0.5458 mL	2.7290 mL
100 mM	0.0273 mL	0.1365 mL	0.2729 mL	1.3645 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc