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Tau Protein, Human, Recombinant (His)

Catalog No. TMPY-03425
Synonyms: PPND, FTDP-17, MTBT1, DDPAC, MAPTL, MTBT2, microtubule-associated protein tau, PPP1R103, MAPT, MSTD, TAU

MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

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Tau Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
50 μg In stock $ 386.00
100 μg 5 days $ 660.00
200 μg 5 days $ 1,120.00
500 μg 5 days $ 2,270.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Testing in progress
Description MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.
Species Human
Expression System E. coli
Tag N-His
Accession Number P10636-2
Synonyms PPND, FTDP-17, MTBT1, DDPAC, MAPTL, MTBT2, microtubule-associated protein tau, PPP1R103, MAPT, MSTD, TAU
Construction mature form of Human MAPT (NP_058525.1) (Ala2-Leu352)
Protein Purity > 85 % as determined by SDS-PAGE

Molecular Weight 38.7 kDa (predicted)
Endotoxin Please contact us for more information.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.

References and Literature

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Keywords

Tau Protein, Human, Recombinant (His) FTDP17 PPND FTDP-17 MTBT-1 MTBT1 PPP1R 103 DDPAC MAPTL PPP1R-103 MTBT2 microtubule-associated protein tau FTDP 17 PPP1R103 MTBT 1 MAPT MTBT 2 MSTD TAU MTBT-2 recombinant recombinant-proteins proteins protein

 

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