Shopping Cart

Your shopping cart is currently empty

NAN-190 hydrobromide

Name: NAN-190 hydrobromide
Brand: TargetMol
SKU: T12172
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T12172Cas No. 115338-32-4

NAN-190 hydrobromide is an antagonist of serotonin receptor 5-HT.

NAN-190 hydrobromide

Copy Product Info

😃Good

Purity: 95.20%

Catalog No. T12172Cas No. 115338-32-4

NAN-190 hydrobromide is an antagonist of serotonin receptor 5-HT.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	-	In Stock
25 mg	$36	-	In Stock
50 mg	$44	-	In Stock
1 mL x 10 mM (in DMSO)	$30	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:95.20%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

NAN-190 hydrobromide AI Summary

NAN-190 hydrobromide exhibits antiplasmodial activity against multiple strains of Plasmodium falciparum, with IC50 values of 12589.25 nM, 6309.57 nM, and 3162.28 nM against strains 3D7, HB3, and W2 respectively, after 72 hours by SYBR green assay. Additionally, it demonstrates bioactivity by inhibiting the proliferation of Plasmodium falciparum and various human enzymes, including JMJD2E, APE1, ALDH1A1, and HPGD. This compound also modulates cellular functions such as histone modifications, protein interactions, and virus entry, with notable potency in the nanomolar range. Moreover, NAN-190 hydrobromide induces cell cycle arrest in human PC3 cells, leading to accumulations at G1, G2, and S phases at different time points, and shows moderate induction of apoptosis over 24, 48, and 72-hour periods. In antiviral assays, NAN-190 hydrobromide inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells and VERO-6 cells with inhibition rates of 17.7% and 0.31% respectively, at a concentration of 10 µM after 48 hours. It further shows a SARS-CoV-2 3CL-Pro protease inhibition rate of 16.44% at a concentration of 20 µM. These bioactivities suggest potential for continued investigation in drug development, targeting both parasitic and viral pathogens..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

NAN-190 hydrobromide is an antagonist of serotonin receptor 5-HT.

Chemical Properties

Molecular Weight	474.39
Formula	C₂₃H₂₈BrN₃O₃
Cas No.	115338-32-4
Smiles	Br.COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8.33 mg/mL (17.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1080 mL	10.5399 mL	21.0797 mL	105.3985 mL
5 mM	0.4216 mL	2.1080 mL	4.2159 mL	21.0797 mL
10 mM	0.2108 mL	1.0540 mL	2.1080 mL	10.5399 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc