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Anti-A2M Antibody (8U250)
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Catalog No. TMAB-02120
Alias S863 7, FWP007, DKFZp779B086, CPAMD5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, alpha-2-macroglobulin, alpha-2-M, alpha-2 Macroglobulin, alpha 2-Macroglobulin, alpha 2M, alpha 2 M, A2MG_HUMAN, A2M
Anti-A2M Antibody (8U250) is a Rabbit antibody targeting A2M. Anti-A2M Antibody (8U250) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-A2M Antibody (8U250)
Anti-A2M Antibody (8U250)
Copy Product Info😃Good
Catalog No. TMAB-02120Alias S863 7, FWP007, DKFZp779B086, CPAMD5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, alpha-2-macroglobulin, alpha-2-M, alpha-2 Macroglobulin, alpha 2-Macroglobulin, alpha 2M, alpha 2 M, A2MG_HUMAN, A2M
Anti-A2M Antibody (8U250) is a Rabbit antibody targeting A2M. Anti-A2M Antibody (8U250) can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-A2M Antibody (8U250) is a Rabbit antibody targeting A2M. Anti-A2M Antibody (8U250) can be used in WB,IHC-P,IHC-Fr,IF. |
| Synonyms | S863 7, FWP007, DKFZp779B086, CPAMD5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, alpha-2-macroglobulin, alpha-2-M, alpha-2 Macroglobulin, alpha 2-Macroglobulin, alpha 2M, alpha 2 M, A2MG_HUMAN, A2M |
| Ig Type | IgG |
| Clone | 8U250 |
| Reactivity | Human |
| Verified Activity | 1. 25 μg total protein per lane of various lysates (see on figure) probed with A2M monoclonal antibody, unconjugated (TMAB-02120) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. 2. Paraformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with A2M Monoclonal Antibody, Unconjugated (TMAB-02120) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 3. Paraformaldehyde-fixed, paraffin embedded Human Ovarian Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with A2M Monoclonal Antibody, Unconjugated (TMAB-02120) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 4. Paraformaldehyde-fixed, paraffin embedded Human Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with A2M Monoclonal Antibody, Unconjugated (TMAB-02120) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 5. Paraformaldehyde-fixed, paraffin embedded Human Kidney Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with A2M Monoclonal Antibody, Unconjugated (TMAB-02120) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Tissue Specificity | Secreted in plasma |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]. |
| Immunogen | A synthesized peptide: human alpha 2 Macroglobulin |
| Antigen Species | Human |
| Gene Name | A2M |
| Gene ID | |
| Protein Name | alpha-2-macroglobulin |
| Uniprot ID | |
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Molecular Weight | Theoretical: 160 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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