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Anti-A2M Antibody (8U250)
(Synonyms: S863 7, FWP007, DKFZp779B086, CPAMD5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, alpha-2-macroglobulin, alpha-2-M, alpha-2 Macroglobulin, alpha 2-Macroglobulin, alpha 2M, alpha 2 M, A2MG_HUMAN, A2M) Copy Product Info
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Synonyms: S863 7, FWP007, DKFZp779B086, CPAMD5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, alpha-2-macroglobulin, alpha-2-M, alpha-2 Macroglobulin, alpha 2-Macroglobulin, alpha 2M, alpha 2 M, A2MG_HUMAN, A2M
Catalog No. TMAB-02120 Copy Product Info
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Anti-A2M Antibody (8U250) is a Rabbit antibody targeting A2M. Anti-A2M Antibody (8U250) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-A2M Antibody
(8U250)
(8U250)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-A2M Antibody (8U250) is a Rabbit antibody targeting A2M. Anti-A2M Antibody (8U250) can be used in WB,IHC-P,IHC-Fr,IF. |
| Synonyms | S863 7, FWP007, DKFZp779B086, CPAMD5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, alpha-2-macroglobulin, alpha-2-M, alpha-2 Macroglobulin, alpha 2-Macroglobulin, alpha 2M, alpha 2 M, A2MG_HUMAN, A2M |
| Ig Type | IgG |
| Clone | 8U250 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Tissue Specificity | Secreted in plasma |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]. |
| Immunogen | A synthesized peptide: human alpha 2 Macroglobulin |
| Antigen Species | Human |
| Gene Name | A2M |
| Gene ID | |
| Protein Name | alpha-2-macroglobulin |
| Uniprot ID | |
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Molecular Weight | Theoretical: 160 kDa. Actual: 180 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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