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CCG-50014

Name: CCG-50014
Brand: TargetMol
SKU: T6434
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6434Cas No. 883050-24-6

Alias CCG 50014

CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

CCG-50014

🥰Excellent

Purity: 98.53%

Catalog No. T6434Alias CCG 50014Cas No. 883050-24-6

CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$419	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.53%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
Targets&IC50	RGS16:3.5 μM, RGS4:30 nM, RGS8:11 μM, RGS19:0.12 μM
In vitro	CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys?). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4?Gαo protein?protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. [1] [2]
Synonyms	CCG 50014

Chemical Properties

Molecular Weight	316.35
Formula	C₁₆H₁₃FN₂O₂S
Cas No.	883050-24-6
Smiles	Cc1ccc(cc1)-n1sc(=O)n(Cc2ccc(F)cc2)c1=O
Relative Density.	1.398 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 59 mg/mL (186.5 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1611 mL	15.8053 mL	31.6106 mL	158.0528 mL
5 mM	0.6322 mL	3.1611 mL	6.3221 mL	31.6106 mL
10 mM	0.3161 mL	1.5805 mL	3.1611 mL	15.8053 mL
20 mM	0.1581 mL	0.7903 mL	1.5805 mL	7.9026 mL
50 mM	0.0632 mL	0.3161 mL	0.6322 mL	3.1611 mL
100 mM	0.0316 mL	0.1581 mL	0.3161 mL	1.5805 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc