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Corticotropin-releasing factor (human) (acetate)

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Catalog No. T37111

Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.

Corticotropin-releasing factor (human) (acetate)
Other Forms of Corticotropin-releasing factor (human) (acetate):

Corticotropin-releasing factor (human) (acetate)

😃Good
Catalog No. T37111
Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
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1 mg$276Backorder
5 mg$741Backorder
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Product Introduction

Bioactivity
Description
Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
In vitro
CRF enhances the excitability of type II dlBNST neurons via the activation of the AC-cAMP-PKA pathway, leading to pain-induced aversive responses[1].
In vivo
In rats that received an injection of CRF (1 nmol/side), the duration spent in the drug-paired compartment during the test session (314±22 s) was significantly reduced compared to the time spent in the same compartment during the preconditioning session (520±18 s)[1].
Chemical Properties
Relative Density.no data available
SequenceH-DL-Ser-DL-Glu-DL-Glu-DL-Pro-DL-Pro-DL-xiIle-DL-Ser-DL-Leu-DL-Asp-DL-Leu-DL-xiThr-DL-Phe-DL-His-DL-Leu-DL-Leu-DL-Arg-DL-Glu-DL-Val-DL-Leu-DL-Glu-DL-Met-DL-Ala-DL-Arg-DL-Ala-DL-Glu-DL-Gln-DL-Leu-DL-Ala-DL-Gln-DL-Gln-DL-Ala-DL-His-DL-Ser-DL-Asn-DL-Arg-DL-L
Sequence ShortSEEPPXSLDLXFHLLREVLEMARAEQLAQQAHSNRKLMEXX
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Corticotropin-releasing factorCorticotropin releasing factor (human) (acetate)Corticotropinreleasing factor (human) (acetate)
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