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N-Desmethyl imatinib

Name: N-Desmethyl imatinib
Brand: TargetMol
SKU: T11641
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11641Cas No. 404844-02-6

Alias Norimatinib, Imatinib metabolite N-Desmethyl imatinib

N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.

N-Desmethyl imatinib

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Purity: 98.60%

Catalog No. T11641Alias Norimatinib, Imatinib metabolite N-Desmethyl imatinibCas No. 404844-02-6

N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
5 mg	$178	In Stock	In Stock
10 mg	$336	In Stock	In Stock
25 mg	$569	In Stock	In Stock
50 mg	$818	In Stock	In Stock
100 mg	$1,130	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$188	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.60%

Appearance:solid

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COA HNMR LCMS

Product Introduction

N-Desmethyl imatinib AI Summary

N-Desmethyl imatinib inhibits the LRRK2 G2019S mutant with an IC50 of 3300.0 nM and the wild type LRRK2 with an IC50 of 4600.0 nM. The compound demonstrates a selectivity ratio, showing a preference for inhibition of the LRRK2 G2019S mutant compared to the wild type LRRK2, with this ratio being less than 2.6..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
Synonyms	Norimatinib, Imatinib metabolite N-Desmethyl imatinib

Chemical Properties

Molecular Weight	479.58
Formula	C₂₈H₂₉N₇O
Cas No.	404844-02-6
Smiles	Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(n1)-c1cccnc1
Relative Density.	1.269g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 99 mg/mL (206.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0852 mL	10.4258 mL	20.8516 mL	104.2579 mL
5 mM	0.4170 mL	2.0852 mL	4.1703 mL	20.8516 mL
10 mM	0.2085 mL	1.0426 mL	2.0852 mL	10.4258 mL
20 mM	0.1043 mL	0.5213 mL	1.0426 mL	5.2129 mL
50 mM	0.0417 mL	0.2085 mL	0.4170 mL	2.0852 mL
100 mM	0.0209 mL	0.1043 mL	0.2085 mL	1.0426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc