Shopping Cart
Remove All
Your shopping cart is currently empty
TNKS-IN-1
Copy Product Info
🥰Excellent
Synonyms:
Catalog No. T28989 Copy Product Info
Purity: 99.98%
🥰Excellent
TNKS-IN-1 is a selective and potent tankyrase (TNKS1/TNKS2) inhibitor with IC50 values of 7.9 nM and 8.7 nM. TNKS-IN-1 induces axin2 accumulation with an EC50 of 1500 nM. TNKS-IN-1 antagonizes the Wnt signal transduction pathway by stabilizing axin proteins and promoting β-catenin degradation. TNKS-IN-1 is used in colorectal cancer research models to investigate Wnt/β-catenin pathway regulation, tankyrase-mediated protein turnover, and downstream transcriptional control mechanisms in oncogenic signaling systems.
Cas No. 59455-93-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
Select Batch
Purity:99.98%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TNKS-IN-1 is a selective and potent tankyrase (TNKS1/TNKS2) inhibitor with IC50 values of 7.9 nM and 8.7 nM. TNKS-IN-1 induces axin2 accumulation with an EC50 of 1500 nM. TNKS-IN-1 antagonizes the Wnt signal transduction pathway by stabilizing axin proteins and promoting β-catenin degradation. TNKS-IN-1 is used in colorectal cancer research models to investigate Wnt/β-catenin pathway regulation, tankyrase-mediated protein turnover, and downstream transcriptional control mechanisms in oncogenic signaling systems. |
| Targets & IC50 | TNKS2:8.7 nM, TNKS1:7.9 nM, PARP-1:>10000 nM |
| In vitro | Methods：In vitro enzyme activity assays and cellular experiments were conducted to evaluate the inhibitory effects of TNKS-IN-1 on TNKS1, TNKS2 and PARP1, as well as its intracellular target inhibition. Results： 1.After 1-hour treatment, TNKS-IN-1 potently inhibited human TNKS1 and TNKS2 with IC₅₀ values of 7.9 nM and 8.7 nM, respectively. Its IC₅₀ against PARP1 was greater than 10000 nM. 2.Treatment with TNKS-IN-1 for 24 hours induced axin2 accumulation in DLD1 cells with an EC₅₀ of 1500 nM, confirming its intracellular tankyrase inhibitory activity [1]. |
| Molecular Weight | 278.35 |
| Formula | C18H18N2O |
| Cas No. | 59455-93-5 |
| Smiles | O=C1N=C(NC=2C=CC=CC12)C=3C=CC(=CC3)C(C)(C)C |
| Relative Density. | 1.13 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: TNKS-IN-1 chemical structure | TNKS-IN-1 in vitro | TNKS-IN-1 formula | TNKS-IN-1 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.