JLJ648

Name: JLJ648
Brand: TargetMol
SKU: T213603
Rating: 4.5 (1 reviews)

Catalog No. T213603 Copy Product Info

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JLJ648 is a Gag-Pol dimerization agent with antiviral properties. It inhibits the replication of HIV and induces pyroptosis in infected cells. JLJ648 is useful in research related to infections, such as the study of human immunodeficiency virus (HIV).

JLJ648

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Catalog No. T213603

JLJ648

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

In vitro

JLJ648 inhibits HIV-1 replication in MT-2 cells with an EC50 value of 1.6 nM (3 days). It exhibits low cytotoxicity in MT-2 and THP-1 cells, with CC50 values greater than 100 μM, and a CC50 value of 22.9 μM in primary CD4+ T cells. JLJ648 promotes the homodimerization of the recombinant HIV-1 reverse transcriptase p66 subunit, with an EC50 value of 95 nM (17 hours). It induces HIV protease-dependent pyroptosis in THP-1 clone14 cells and HIV-infected primary CD4+ T cells, with an EC50 value of 86 nM (3-4 hours). Additionally, JLJ648 binds to HIV-1 reverse transcriptase p66 (50 μM, 12 hours), forming two oligomeric structures, including subunits in the catalytic/structural conformation and a "double zipper" form homotetramer.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc