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SR15006

🥰Excellent
Catalog No. T60037Cas No. 2505001-54-5

SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).

SR15006

SR15006

🥰Excellent
Purity: 99.87%
Catalog No. T60037Cas No. 2505001-54-5
SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$41In StockIn Stock
25 mg$83In StockIn Stock
50 mg$156In StockIn Stock
100 mg$233In StockIn Stock
1 mL x 10 mM (in DMSO)$39In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.87%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).
In vitro
In DLD-1 CRC cells, SR15006 (1 μM or 10 μM) causes a significant reduction in the levels of tested cyclins over the course of 72 hours[1].
Chemical Properties
Molecular Weight385.87
FormulaC16H20ClN3O4S
Cas No.2505001-54-5
SmilesCS(=O)(=O)N1CCN(CC1)C(=O)CNC(=O)\C=C\c1cccc(Cl)c1
Relative Density.1.41 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 95 mg/mL (246.20 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.55 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5915 mL12.9577 mL25.9155 mL129.5773 mL
5 mM0.5183 mL2.5915 mL5.1831 mL25.9155 mL
10 mM0.2592 mL1.2958 mL2.5915 mL12.9577 mL
20 mM0.1296 mL0.6479 mL1.2958 mL6.4789 mL
50 mM0.0518 mL0.2592 mL0.5183 mL2.5915 mL
100 mM0.0259 mL0.1296 mL0.2592 mL1.2958 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SR-15006SR15006SR 15006RNASynthesisRNA SynthesisKrüppel-like factorKLF5KLFInhibitorinhibitgrowthDNASynthesisDNA Synthesiscyclinscyclecolorectal cancer cells
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