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DS-1040 Tosylate

Name: DS-1040 Tosylate
Brand: TargetMol
SKU: T11100
Rating: 4.5 (1 reviews)

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Catalog No. T11100Cas No. 1335138-89-0

Alias DS1040 Tosylate

DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFIa) inhibitor, also a fibrinolysis enhancer, inhibiting TAFIa and carboxypeptidase N, reducing fibrin clots in the lungs, useful in thromboembolic disease research.

DS-1040 Tosylate

😃Good

Catalog No. T11100Alias DS1040 TosylateCas No. 1335138-89-0

Pack Size	Price	Availability
2 mg	$119	5 days
25 mg	$614	8-10 weeks
50 mg	$798	8-10 weeks
100 mg	$1,360	8-10 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFIa) inhibitor, also a fibrinolysis enhancer, inhibiting TAFIa and carboxypeptidase N, reducing fibrin clots in the lungs, useful in thromboembolic disease research.
Targets&IC50	TAFIa (human):5.92 nM, TAFIa (rat):8.01 nM
In vitro	DS-1040 Tosylate inhibited human carboxypeptidase N (CPN) in vitro with an IC50 of 3.02 mM.[1]
In vivo	Methods: DS-1040 Tosylate (0.016, 0.031, 0.063, 0.13, 0.25, 0.50 mg/kg, intravenous injection) was administered to mice with microthrombosis model to investigate the pharmacokinetic changes in vivo. Results: DS-1040 Tosylate increased plasma D-dimer levels in a dose-dependent manner. ED50 and EDmax were 122 and 221nM, respectively. Methods: DS-1040 Tosylate (0.25, 0.5, 1, 2, 4, 8, 16 mg/kg; oral administration) was administered to mice with microthrombosis model to investigate the pharmacokinetic changes in vivo. Results: DS-1040 Tosylate increased plasma D-dimer levels, with EC50 and ECmax values of 114 and 231 nmol/L, respectively.[1]
Synonyms	DS1040 Tosylate

Chemical Properties

Molecular Weight	465.61
Formula	C₂₃H₃₅N₃O₅S
Cas No.	1335138-89-0
Smiles	S(=O)(=O)(O)C1=CC=C(C)C=C1.C([C@H](CCCN)C(O)=O)C1=CN(C=N1)[C@H]2CC[C@H](C)CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (85.91 mM), Sonication is recommended.

DMSO: 80 mg/mL (171.82 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1477 mL	10.7386 mL	21.4772 mL	107.3860 mL
5 mM	0.4295 mL	2.1477 mL	4.2954 mL	21.4772 mL
10 mM	0.2148 mL	1.0739 mL	2.1477 mL	10.7386 mL
20 mM	0.1074 mL	0.5369 mL	1.0739 mL	5.3693 mL
50 mM	0.0430 mL	0.2148 mL	0.4295 mL	2.1477 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc