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DS-1040 Tosylate

Name: DS-1040 Tosylate
Brand: TargetMol
SKU: T11100
Rating: 4.5 (1 reviews)

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Catalog No. T11100Cas No. 1335138-89-0

Alias DS1040 Tosylate

DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFIa) inhibitor, also a fibrinolysis enhancer, inhibiting TAFIa and carboxypeptidase N, reducing fibrin clots in the lungs, useful in thromboembolic disease research.

DS-1040 Tosylate

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Catalog No. T11100Alias DS1040 TosylateCas No. 1335138-89-0

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$119	5 days	5 days
25 mg	$614	8-10 weeks	8-10 weeks
50 mg	$798	8-10 weeks	8-10 weeks
100 mg	$1,360	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFIa) inhibitor, also a fibrinolysis enhancer, inhibiting TAFIa and carboxypeptidase N, reducing fibrin clots in the lungs, useful in thromboembolic disease research.
Targets&IC50	TAFIa (human):5.92 nM, TAFIa (rat):8.01 nM
In vitro	DS-1040 Tosylate inhibited human carboxypeptidase N (CPN) in vitro with an IC50 of 3.02 mM.[1]
In vivo	Methods: DS-1040 Tosylate (0.016, 0.031, 0.063, 0.13, 0.25, 0.50 mg/kg, intravenous injection) was administered to mice with microthrombosis model to investigate the pharmacokinetic changes in vivo. Results: DS-1040 Tosylate increased plasma D-dimer levels in a dose-dependent manner. ED50 and EDmax were 122 and 221nM, respectively. Methods: DS-1040 Tosylate (0.25, 0.5, 1, 2, 4, 8, 16 mg/kg; oral administration) was administered to mice with microthrombosis model to investigate the pharmacokinetic changes in vivo. Results: DS-1040 Tosylate increased plasma D-dimer levels, with EC50 and ECmax values of 114 and 231 nmol/L, respectively.[1]
Synonyms	DS1040 Tosylate

Chemical Properties

Molecular Weight	465.61
Formula	C₂₃H₃₅N₃O₅S
Cas No.	1335138-89-0
Smiles	S(=O)(=O)(O)C1=CC=C(C)C=C1.C([C@H](CCCN)C(O)=O)C1=CN(C=N1)[C@H]2CC[C@H](C)CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (85.91 mM), Sonication is recommended.

DMSO: 80 mg/mL (171.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1477 mL	10.7386 mL	21.4772 mL	107.3860 mL
5 mM	0.4295 mL	2.1477 mL	4.2954 mL	21.4772 mL
10 mM	0.2148 mL	1.0739 mL	2.1477 mL	10.7386 mL
20 mM	0.1074 mL	0.5369 mL	1.0739 mL	5.3693 mL
50 mM	0.0430 mL	0.2148 mL	0.4295 mL	2.1477 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc