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Tris(2,4-di-tert-butylphenyl)phosphate

🥰Excellent
Catalog No. T13206Cas No. 95906-11-9
Alias TDTBPP

Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP) isolated from Vitex negundoL inhibits secretory phospholipase A2 (sPLA2). Tris(2,4-di-tert-butylphenyl)phosphate has anti-inflammatory activity.

Tris(2,4-di-tert-butylphenyl)phosphate

Tris(2,4-di-tert-butylphenyl)phosphate

🥰Excellent
Purity: 99.73%
Catalog No. T13206Alias TDTBPPCas No. 95906-11-9
Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP) isolated from Vitex negundoL inhibits secretory phospholipase A2 (sPLA2). Tris(2,4-di-tert-butylphenyl)phosphate has anti-inflammatory activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$30In StockIn Stock
25 mg$42In StockIn Stock
50 mg$61In StockIn Stock
100 mg$89In StockIn Stock
500 mg$218In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.73%
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Product Introduction

Bioactivity
Description
Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP) isolated from Vitex negundoL inhibits secretory phospholipase A2 (sPLA2). Tris(2,4-di-tert-butylphenyl)phosphate has anti-inflammatory activity.
In vitro
METHODS: KGN, MA-10 and C18-4 cells were treated with Tris(2,4-di-tert-butylphenyl)phosphate (0.1-100 µM) for 48 h. Cell counts were assayed by Hoechst 33342 stained.
RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate was not cytotoxic to any of the 3 cell lines. [1]
In vivo
METHODS: To assay acute anti-inflammatory activity in vivo, Tris(2,4-di-tert-butylphenyl)phosphate (50-70 mg/kg, 0.1% sodium carboxymethyl cellulose in 1M phosphate buffer pH 7.2) was The carrageenan-induced foot-plantar edema model in rats was administered.
RESULTS: Tris(2,4-di-tert-butylphenyl) phosphate at doses of 50 mg/kg and 70 mg/kg exhibited significant anti-inflammatory activity in the carrageenan-induced foot-plantar edema model. tris(2,4-di-tert-butylphenyl) phosphate significantly reduced the volume of raw paw edema. [2]
SynonymsTDTBPP
Chemical Properties
Molecular Weight662.92
FormulaC42H63O4P
Cas No.95906-11-9
SmilesP(OC1=C(C(C)(C)C)C=C(C(C)(C)C)C=C1)(OC2=C(C(C)(C)C)C=C(C(C)(C)C)C=C2)(OC3=C(C(C)(C)C)C=C(C(C)(C)C)C=C3)=O
Relative Density.1.007 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.
Ethanol: 100 mg/mL (150.85 mM), Sonication is recommended.
In Vivo Formulation
10% EtOH+90% Corn Oil: 3.3 mg/mL (4.98 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol
1mg5mg10mg50mg
1 mM1.5085 mL7.5424 mL15.0848 mL75.4239 mL
5 mM0.3017 mL1.5085 mL3.0170 mL15.0848 mL
10 mM0.1508 mL0.7542 mL1.5085 mL7.5424 mL
20 mM0.0754 mL0.3771 mL0.7542 mL3.7712 mL
50 mM0.0302 mL0.1508 mL0.3017 mL1.5085 mL
100 mM0.0151 mL0.0754 mL0.1508 mL0.7542 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Tris(2,4-di-tert-butylphenyl)phosphateTris(2,4ditertbutylphenyl)phosphateTris(2,4 di tert butylphenyl)phosphatesPLA2secretoryPhospholipasemolecularInhibitorinhibitdockinganti-inflammatory
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