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CGP 78608 hydrochloride

Name: CGP 78608 hydrochloride
Brand: TargetMol
SKU: T10781
Price: 87 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10781Cas No. 1135278-54-4

Alias PAMQX

CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).

CGP 78608 hydrochloride

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Purity: 99.85%

Catalog No. T10781Alias PAMQXCas No. 1135278-54-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$87	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$243	In Stock	-
25 mg	$535	In Stock	-
50 mg	$773	8-10weeks	8-10weeks
100 mg	$1,080	8-10weeks	8-10weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.85%

ee:100%

Resource Download

COA CSFC HPLC HNMR

Product Introduction

Bioactivity

Description	CGP 78608 hydrochloride is a specific antagonist at the glycine binding site of the NMDA receptor (IC50 = 6 nM). CGP 78608 hydrochloride exhibits anticonvulsant activity. CGP 78608 hydrochloride potentiates GluN1/GluN3A-mediated glycine currents (estimated EC50 = 26.3 nM).
Targets&IC50	NMDAR:6 nM
In vitro	CGP 78608 hydrochloride reduces ammonia-dependent cGMP synthesis and relieves ammonia neurotoxicity[2]. CGP-78608 hydrochloride reduces glycine sensitivity of GluN1 and GluN3A receptors[3].
In vivo	CGP-78608 (i.p.) exhibits anticonvulsant effects in the electroshock-induced convulsions assay in mice[1].
Synonyms	PAMQX

Chemical Properties

Molecular Weight	414.58
Formula	C₁₁H₁₄BrClN₃O₅P
Cas No.	1135278-54-4
Smiles	C(N[C@@H](P(=O)(O)O)C)C1=C2C(NC(=O)C(=O)N2)=CC(Br)=C1.Cl
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 37.4 mg/mL (90.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4121 mL	12.0604 mL	24.1208 mL	120.6040 mL
5 mM	0.4824 mL	2.4121 mL	4.8242 mL	24.1208 mL
10 mM	0.2412 mL	1.2060 mL	2.4121 mL	12.0604 mL
20 mM	0.1206 mL	0.6030 mL	1.2060 mL	6.0302 mL
50 mM	0.0482 mL	0.2412 mL	0.4824 mL	2.4121 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc