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Panaxadiol

Name: Panaxadiol
Brand: TargetMol
SKU: T2763
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2763Cas No. 19666-76-3

Alias 20(R)-Panaxadiol

Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medicinal herb Panax ginseng.

Panaxadiol

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Purity: 99.9%

Catalog No. T2763Alias 20(R)-PanaxadiolCas No. 19666-76-3

Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medicinal herb Panax ginseng.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$37	In Stock	In Stock
50 mg	$50	In Stock	In Stock
100 mg	$70	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Panaxadiol AI Summary

Panaxadiol demonstrates a broad range of biological activities. It exhibits moderate to weak inhibition against HIV1 and HCV proteases with IC50 values exceeding 217100.0 nM. The compound also shows cytotoxicity against various human cancer cell lines, including ES2, U2OS, HepG2, and A549, with IC50 values ranging from 5610.0 nM to 43130.0 nM, and 12.45% to 68.98% cell viability at 25 uM and 50 uM concentrations after 48 hours. Furthermore, it displays inhibitory activity against electric eel AChE and horse BChE, with inhibition percentages of 7.82% and 12.14% at 2 mg/ml respectively. Additionally, Panaxadiol exhibits cytotoxic effects against MCF7 and A549 cancer cell lines and is less effective against 8901, U87, HeLa, and IOSE-144 cell lines. It also activates human CK-MM enzyme activity in a dose-dependent manner, with a 7.1% increase at 20 uM, 14.4% at 40 uM, and 15.4% at 80 uM. The compound inhibits hypoxia-induced HIF1alpha transcriptional activity in Hep3B cells with an IC50 of 9100.0 nM and has an IC50 value of 31700.0 nM under normoxic conditions. Notably, Panaxadiol shows neuroprotective activity against amyloid beta (25 to 35)-induced apoptosis in rat PC12 cells, reducing the apoptosis rate by 5.4% at 15 uM after 15 minutes of incubation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medicinal herb Panax ginseng.
Synonyms	20(R)-Panaxadiol

Chemical Properties

Molecular Weight	460.73
Formula	C₃₀H₅₂O₃
Cas No.	19666-76-3
Smiles	[H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)C[C@]1([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]21C)[C@@]1(C)CCCC(C)(C)O1
Relative Density.	1.025 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20 mg/mL (43.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.1705 mL	10.8523 mL	21.7047 mL	108.5234 mL
5 mM	0.4341 mL	2.1705 mL	4.3409 mL	21.7047 mL
10 mM	0.2170 mL	1.0852 mL	2.1705 mL	10.8523 mL
20 mM	0.1085 mL	0.5426 mL	1.0852 mL	5.4262 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc