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WS3

Name: WS3
Brand: TargetMol
SKU: T2055
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2055Cas No. 1421227-52-2

WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

WS3

🥰Excellent

Purity: 99.94%

Catalog No. T2055Cas No. 1421227-52-2

WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

Pack Size	Price	Availability
5 mg	$37	In Stock
10 mg	$67	In Stock
25 mg	$126	In Stock
50 mg	$216	In Stock
100 mg	$347	In Stock
200 mg	$515	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock

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Purity:99.94%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
Targets&IC50	Proliferation (β cells):28 nM(ec50)
In vivo	In the mouse β-cell line R7T1, WS3 induces cell proliferation with an EC50 of 0.074 μM. Additionally, WS3 reversibly induces cell proliferation in primary embryonic and adult retinal pigment epithelial cells.
Cell Research	R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference)

Chemical Properties

Molecular Weight	569.58
Formula	C₂₈H₃₀F₃N₇O₃
Cas No.	1421227-52-2
Smiles	C(C1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC=3C=C(NC(=O)C4CC4)N=CN3)C=C2)=O)C=C1)N5CCN(C)CC5
Relative Density.	1.423 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (163.28 mM), Sonication is recommended.

Ethanol: 74 mg/mL (129.92 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7557 mL	8.7784 mL	17.5568 mL	87.7840 mL
5 mM	0.3511 mL	1.7557 mL	3.5114 mL	17.5568 mL
10 mM	0.1756 mL	0.8778 mL	1.7557 mL	8.7784 mL
20 mM	0.0878 mL	0.4389 mL	0.8778 mL	4.3892 mL
50 mM	0.0351 mL	0.1756 mL	0.3511 mL	1.7557 mL
100 mM	0.0176 mL	0.0878 mL	0.1756 mL	0.8778 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc