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Anti-UNC5B Polyclonal Antibody
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Catalog No. TMAB-01935
Alias UNC5H2, unc-5 homolog B (C. elegans), p53RDL1
Anti-UNC5B Polyclonal Antibody is a Rabbit antibody targeting UNC5B. Anti-UNC5B Polyclonal Antibody can be used in WB.
Anti-UNC5B Polyclonal Antibody
Anti-UNC5B Polyclonal Antibody
😃Good
Catalog No. TMAB-01935Alias UNC5H2, unc-5 homolog B (C. elegans), p53RDL1
Anti-UNC5B Polyclonal Antibody is a Rabbit antibody targeting UNC5B. Anti-UNC5B Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-UNC5B Polyclonal Antibody is a Rabbit antibody targeting UNC5B. Anti-UNC5B Polyclonal Antibody can be used in WB. |
| Synonyms | UNC5H2, unc-5 homolog B (C. elegans), p53RDL1 |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Dog,Pig,Horse,Rabbit) |
| Verified Activity | 25 μg total protein per Lane of various lysates probed with UNC5B polyclonal antibody, unconjugated (TMAB-01935) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. Note=Associated with lipid raft. |
| Tissue Specificity | Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011] |
| Immunogen | KLH conjugated synthetic peptide: human UNC5B |
| Antigen Species | Human |
| Gene Name | UNC5B |
| Gene ID | |
| Protein Name | Netrin receptor UNC5B |
| Uniprot ID | |
| Biology Area | Endothelium,Axonal Guidance Proteins,Neural Signal Transduction |
| Function | FunctionReceptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. |
| Molecular Weight | Theoretical: 101 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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