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Anti-Nitro-Alpha-synuclein (Tyr39) Polyclonal Antibody
(Synonyms: PD1, PARK4, PARK1, NACP) Copy Product Info
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Synonyms: PD1, PARK4, PARK1, NACP
Catalog No. TMAB-01239 Copy Product Info
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Anti-Nitro-Alpha-synuclein (Tyr39) Polyclonal Antibody is a Rabbit antibody targeting Nitro-Alpha-synuclein (Tyr39). Anti-Nitro-Alpha-synuclein (Tyr39) Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P.
Anti-Nitro-Alpha-synuclein
(Tyr39) Polyclonal Antibody
(Tyr39) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Nitro-Alpha-synuclein (Tyr39) Polyclonal Antibody is a Rabbit antibody targeting Nitro-Alpha-synuclein (Tyr39). Anti-Nitro-Alpha-synuclein (Tyr39) Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P. |
| Synonyms | PD1, PARK4, PARK1, NACP |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1ug/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons. |
| Tissue Specificity | Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]. |
| Immunogen | KLH conjugated Synthesised nitrylpeptide: human SNCA around the nitrosation site of Tyr39 |
| Antigen Species | Human |
| Gene Name | SNCA |
| Gene ID | |
| Protein Name | alpha-synuclein |
| Uniprot ID | |
| Biology Area | Tangles & Tau,Synuclein |
| Function | May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. |
| Molecular Weight | Theoretical: 15 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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