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7-Chlorokynurenic acid

Name: 7-Chlorokynurenic acid
Brand: TargetMol
SKU: T10191L
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10191LCas No. 18000-24-3

Alias 7-CKA, 7-chloro-4-hydroxy-2-carboxyquinoline

7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.

7-Chlorokynurenic acid

🥰Excellent

Purity: 98.83%

Catalog No. T10191LAlias 7-CKA, 7-chloro-4-hydroxy-2-carboxyquinolineCas No. 18000-24-3

Pack Size	Price	Availability
5 mg	$38	In Stock
10 mg	$61	In Stock
25 mg	$128	In Stock
50 mg	$239	In Stock
100 mg	$430	In Stock
200 mg	$623	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.83%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.
Targets&IC50	Glycine B coagonist site of NMDA receptor:0.56 μM(ki), Reuptake of glutamate:（ki）0.59 μM
In vivo	In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response[3].
Synonyms	7-CKA, 7-chloro-4-hydroxy-2-carboxyquinoline

Chemical Properties

Molecular Weight	223.61
Formula	C₁₀H₆ClNO₃
Cas No.	18000-24-3
Smiles	OC(=O)c1cc(O)c2ccc(Cl)cc2n1
Relative Density.	1.549 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (67.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4721 mL	22.3604 mL	44.7207 mL	223.6036 mL
5 mM	0.8944 mL	4.4721 mL	8.9441 mL	44.7207 mL
10 mM	0.4472 mL	2.2360 mL	4.4721 mL	22.3604 mL
20 mM	0.2236 mL	1.1180 mL	2.2360 mL	11.1802 mL
50 mM	0.0894 mL	0.4472 mL	0.8944 mL	4.4721 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc