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7-Chlorokynurenic acid

Name: 7-Chlorokynurenic acid
Brand: TargetMol
SKU: T10191L
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10191LCas No. 18000-24-3

Alias 7-CKA, 7-chloro-4-hydroxy-2-carboxyquinoline

7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.

7-Chlorokynurenic acid

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Purity: 98.83%

Catalog No. T10191LAlias 7-CKA, 7-chloro-4-hydroxy-2-carboxyquinolineCas No. 18000-24-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	-	In Stock
10 mg	$61	-	In Stock
25 mg	$128	-	In Stock
50 mg	$239	-	In Stock
100 mg	$430	-	In Stock
200 mg	$623	-	In Stock
1 mL x 10 mM (in DMSO)	$67	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.83%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.
Targets&IC50	Glycine B coagonist site of NMDA receptor:0.56 μM(ki), Reuptake of glutamate:（ki）0.59 μM
In vivo	In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response[3].
Synonyms	7-CKA, 7-chloro-4-hydroxy-2-carboxyquinoline

Chemical Properties

Molecular Weight	223.61
Formula	C₁₀H₆ClNO₃
Cas No.	18000-24-3
Smiles	OC(=O)c1cc(O)c2ccc(Cl)cc2n1
Relative Density.	1.549 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (67.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4721 mL	22.3604 mL	44.7207 mL	223.6036 mL
5 mM	0.8944 mL	4.4721 mL	8.9441 mL	44.7207 mL
10 mM	0.4472 mL	2.2360 mL	4.4721 mL	22.3604 mL
20 mM	0.2236 mL	1.1180 mL	2.2360 mL	11.1802 mL
50 mM	0.0894 mL	0.4472 mL	0.8944 mL	4.4721 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc