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Anti-Phospho-IGF1R/CD221 (Tyr1280) Polyclonal Antibody

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Catalog No. TMAC-02096

Anti-Phospho-IGF1R/CD221 (Tyr1280) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IGF1R/CD221 (Tyr1280). Anti-Phospho-IGF1R/CD221 (Tyr1280) Polyclonal Antibody can be used in WB.

Anti-Phospho-IGF1R/CD221 (Tyr1280) Polyclonal Antibody

Anti-Phospho-IGF1R/CD221 (Tyr1280) Polyclonal Antibody

😃Good
Catalog No. TMAC-02096
Anti-Phospho-IGF1R/CD221 (Tyr1280) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IGF1R/CD221 (Tyr1280). Anti-Phospho-IGF1R/CD221 (Tyr1280) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2187-10 days
100 μL$3167-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-IGF1R/CD221 (Tyr1280) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IGF1R/CD221 (Tyr1280). Anti-Phospho-IGF1R/CD221 (Tyr1280) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundThis receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y(p)-Y-S) derived from Human IGF-1R
Antigen Species
human
Uniprot ID
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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