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mSIRK

Name: mSIRK
Brand: TargetMol
SKU: T80548
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T80548Cas No. 593267-11-9

Alias G-Protein βγ Binding Peptide

mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable activator of ERK 1/2 with an EC50 of 2.5-5 μM. It disrupts the interaction between the α and βγ subunits, facilitating α subunit dissociation without inducing nucleotide exchange [1].

mSIRK

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Purity: 99.26%

Catalog No. T80548Alias G-Protein βγ Binding PeptideCas No. 593267-11-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$297	In Stock	In Stock
100 mg	$453	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.26%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable activator of ERK 1/2 with an EC50 of 2.5-5 μM. It disrupts the interaction between the α and βγ subunits, facilitating α subunit dissociation without inducing nucleotide exchange [1].
Synonyms	G-Protein βγ Binding Peptide

Chemical Properties

Molecular Weight	1948.31
Formula	C₉₃H₁₅₀N₂₀O₂₅
Cas No.	593267-11-9
Smiles	C([C@H](CC1=CC=C(O)C=C1)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCCCCCC)=O)CO)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCCCN)=O)C)=O)CC(C)C)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)=O)(=O)N2[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)CC(O)=O)=O)CCC2
Sequence	{Myr}-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp
Sequence Short	{Myr}-SIRKALNILGYPDYD

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (51.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5133 mL	2.5663 mL	5.1327 mL	25.6633 mL
5 mM	0.1027 mL	0.5133 mL	1.0265 mL	5.1327 mL
10 mM	0.0513 mL	0.2566 mL	0.5133 mL	2.5663 mL
20 mM	0.0257 mL	0.1283 mL	0.2566 mL	1.2832 mL
50 mM	0.0103 mL	0.0513 mL	0.1027 mL	0.5133 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc