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4,4-Dimethyl-2-cyclopenten-1-one (Synonyms: 4,4-Dimethylcyclopent-2-enone)

Name: 4,4-Dimethyl-2-cyclopenten-1-one
Brand: TargetMol
SKU: T78502
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T78502 Copy Product Info

Purity: 99.98%

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4,4-Dimethyl-2-cyclopenten-1-one is a natural product derived from Apocyniveneti Folium that exhibits antitumor activity. 4,4-Dimethyl-2-cyclopenten-1-one selectively kills tumor cells (HSC-2, HL-60). The CC50 (50% cytotoxic concentration) values for 4,4-Dimethyl-2-cyclopenten-1-one are 43.8 μg/mL, 152 μg/mL, 118 μg/mL, and 14.0 μg/mL (HSC-2, HSC-3, HSG, HL-60).

4,4-Dimethyl-2-cyclopenten-1-one

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Catalog No. T78502

Synonyms 4,4-Dimethylcyclopent-2-enone

Cas No. 22748-16-9

Pack Size	Price	USA Stock	Global Stock	Quantity
25 mg	$42	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.98%

Appearance:Liquid

Color:Transparent

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	4,4-Dimethyl-2-cyclopenten-1-one is a natural product derived from Apocyniveneti Folium that exhibits antitumor activity. 4,4-Dimethyl-2-cyclopenten-1-one selectively kills tumor cells (HSC-2, HL-60). The CC50 (50% cytotoxic concentration) values for 4,4-Dimethyl-2-cyclopenten-1-one are 43.8 μg/mL, 152 μg/mL, 118 μg/mL, and 14.0 μg/mL (HSC-2, HSC-3, HSG, HL-60).
In vitro	4,4-Dimethyl-2-cyclopenten-1-one selectively kills tumor cells (HSC-2, HL-60). The CC50 (50% cytotoxic concentration) values for 4,4-dimethyl-2-cyclopenten-1-one were 43.8 μg/mL, 152 μg/mL, 118 μg/mL, and 14.0 μg/mL for HSC-2, HSC-3, HSG, HL-60, HGF, and normal cells (HPC), and 177 μg/mL and 123 μg/mL, respectively. [1]
Synonyms	4,4-Dimethylcyclopent-2-enone

Chemical Properties

Molecular Weight	110.15
Formula	C₇H₁₀O
Cas No.	22748-16-9
Smiles	O=C1C=CC(C)(C)C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (726.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.0785 mL	45.3926 mL	90.7853 mL	453.9265 mL
5 mM	1.8157 mL	9.0785 mL	18.1571 mL	90.7853 mL
10 mM	0.9079 mL	4.5393 mL	9.0785 mL	45.3926 mL
20 mM	0.4539 mL	2.2696 mL	4.5393 mL	22.6963 mL
50 mM	0.1816 mL	0.9079 mL	1.8157 mL	9.0785 mL
100 mM	0.0908 mL	0.4539 mL	0.9079 mL	4.5393 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

4,4-Dimethyl-2-cyclopenten-1-one

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