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TC-I 2014

🥰Excellent
Catalog No. T17006Cas No. 1221349-53-6

TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine, human and rat channels respectively).

TC-I 2014

TC-I 2014

🥰Excellent
Purity: 99.07%
Catalog No. T17006Cas No. 1221349-53-6
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine, human and rat channels respectively).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$55In StockIn Stock
5 mg$129In StockIn Stock
10 mg$213In StockIn Stock
25 mg$428In StockIn Stock
50 mg$689In StockIn Stock
100 mg$1,130-In Stock
200 mg$1,530-In Stock
1 mL x 10 mM (in DMSO)$135In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.07%
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Product Introduction

Bioactivity
Description
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine, human and rat channels respectively).
In vitro
TC-I 2014 effectively inhibits cold-induced TRPM8 currents in HEK293 cells stably expressing canine or human TRPM8 (IC50: 0.413 and 1 nM, respectively) [1].
In vivo
Administering TC-I 2014 (10 mg/kg, orally, once) completely prevents icilin-induced WDS [1].
Chemical Properties
Molecular Weight467.41
FormulaC23H19F6N3O
Cas No.1221349-53-6
SmilesFC(F)(F)c1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F
Relative Density.1.48 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 225 mg/mL (481.38 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1394 mL10.6972 mL21.3945 mL106.9725 mL
5 mM0.4279 mL2.1394 mL4.2789 mL21.3945 mL
10 mM0.2139 mL1.0697 mL2.1394 mL10.6972 mL
20 mM0.1070 mL0.5349 mL1.0697 mL5.3486 mL
50 mM0.0428 mL0.2139 mL0.4279 mL2.1394 mL
100 mM0.0214 mL0.1070 mL0.2139 mL1.0697 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

TRPVChannelTRPV ChannelTRPM8TRPChannelTRP ChannelTC-I-2014TC-I2014TC-I 2014TCI 2014TC I 2014
Related Tags: buy TC-I 2014 | purchase TC-I 2014 | TC-I 2014 cost | order TC-I 2014 | TC-I 2014 chemical structure | TC-I 2014 in vivo | TC-I 2014 in vitro | TC-I 2014 formula | TC-I 2014 molecular weight
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