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Brigimadlin
🥰Excellent
Catalog No. T69923Cas No. 2095116-40-6
Alias BI-907828, BI907828, BI 907828
Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase
MDM2-p53 antagonist with antitumor activity.Brigimadlin can be used to study metastatic BTC, PDAC, lung adenocarcinoma, or bladder cancer.
Brigimadlin
🥰Excellent
Purity: 98.17%
Catalog No. T69923Alias BI-907828, BI907828, BI 907828Cas No. 2095116-40-6
Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase
MDM2-p53 antagonist with antitumor activity.Brigimadlin can be used to study metastatic BTC, PDAC, lung adenocarcinoma, or bladder cancer.
MDM2-p53 antagonist with antitumor activity.Brigimadlin can be used to study metastatic BTC, PDAC, lung adenocarcinoma, or bladder cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $162 | In Stock | In Stock | |
| 5 mg | $286 | In Stock | In Stock | |
| 10 mg | $392 | In Stock | In Stock | |
| 25 mg | $643 | In Stock | In Stock | |
| 50 mg | $977 | In Stock | In Stock | |
| 100 mg | $1,460 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $373 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.17%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase MDM2-p53 antagonist with antitumor activity.Brigimadlin can be used to study metastatic BTC, PDAC, lung adenocarcinoma, or bladder cancer. |
| In vitro | Brigimadlin (at concentrations ranging from 0-10 nM; over 48 hours) inhibits the proliferation of BT48, BT50, BT67, BT69, BT89, and BT94, with respective IC50 values of 58.5, 21.1, 37.9, 89.8, 16.7, and 46.8 pM[1]. |
| Synonyms | BI-907828, BI907828, BI 907828 |
| Molecular Weight | 591.46 |
| Formula | C31H25Cl2FN4O3 |
| Cas No. | 2095116-40-6 |
| Smiles | C(N1[C@@]2([C@H]([C@]3([C@@]1(CC=4N3N=C5C4C=CC(C(O)=O)=C5C)[H])[H])C6=C(F)C(Cl)=CC=C6)C=7C(NC2=O)=CC(Cl)=CC7)C8CC8 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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