Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | Inquiry | $ 489.00 | |
1 mg | Inquiry | $ 3,265.00 |
Description | Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |
Species | Human |
Expression System | HEK293 |
Tag | C-His-Avi |
Accession Number | AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGACGVGK |
Synonyms | GTPase Kras, NS3, K-Ras 2, K-RAS2B, RALD, MHC, RASK2, K-RAS4A, CFC2, KRAS2, KRAS, K-RAS4B, KRAS1, C-K-RAS, KI-RAS, K-RAS2A, NS |
Construction | Recombinant Human HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus, tetramer is assembled by biotinylated monomer and streptavidin. It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGACGVGK peptide.[Accession |AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGACGVGK] |
Protein Purity | > 95% as determined by Tris-Bis PAGE> 90% as determined by HPLC |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Supplied as 0.22μm filtered solution in PBS (pH 7.4). |
Stability & Storage |
Valid for 12 months from date of receipt when stored at -80°C.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |
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Please read the User Guide of Recombinant Proteins for more specific information.
HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Tetramer Protein, Human, MHC (His & Avi) GTPase Kras NS3 K-Ras 2 K-RAS2B RALD MHC RASK2 K-RAS4A CFC2 KRAS2 KRAS K-RAS4B KRAS1 C-K-RAS KI-RAS K-RAS2A NS recombinant recombinant-proteins proteins protein