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Anti-Endoglin/CD105 Antibody-APC (4U678)
🥰Excellent
Catalog No. TMAY-00361A
Anti-Endoglin/CD105 Antibody-APC (4U678) is a APC-conjugated Rabbit antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-APC (4U678) can be used in FCM.
Anti-Endoglin/CD105 Antibody-APC (4U678)
Anti-Endoglin/CD105 Antibody-APC (4U678)
🥰Excellent
Catalog No. TMAY-00361A
Anti-Endoglin/CD105 Antibody-APC (4U678) is a APC-conjugated Rabbit antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-APC (4U678) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Endoglin/CD105 Antibody-APC (4U678) is a APC-conjugated Rabbit antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-APC (4U678) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4U678 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD105 expression in HeLa cells. |
| Application | FCM |
| Recommended Dose | 2 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Endoglin / CD105 (rh Endoglin / CD105; TMPY-01384; NP_001108225.1; Met1-Gly586) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types. |
| Conjucates | APC |
| Others Formats | Unconjugated/PerCP/FITC/PE |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human Endoglin / CD105 protein (TMPY-01384) |
| Antigen Species | Human |
| Biology Area | Hemangioblast Markers, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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