Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Angiotensin II 5-valine TFA

🥰Excellent
Catalog No. TP1017L
Alias Angiotensin II 5-valine TFA(58-49-1 free base)

Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.

Angiotensin II 5-valine TFA
Other Forms of Angiotensin II 5-valine TFA:
Angiotensin II 5-valineTP101758-49-1
Backorder
View details

Angiotensin II 5-valine TFA

🥰Excellent
Purity: 99.69%
Catalog No. TP1017LAlias Angiotensin II 5-valine TFA(58-49-1 free base)
Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$32In StockIn Stock
10 mg$41In StockIn Stock
25 mg$44In StockIn Stock
50 mg$46In StockIn Stock
100 mg$70In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.69%
Appearance:Solid
Color:White
Contact us for more batch information

Resource Download

COA HPLC MS

Product Introduction

Bioactivity
Description
Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.
In vivo
By day 12, systolic blood pressure (SBP) increased significantly in Val5-ANG II infused rats (197 +/- 7 mm Hg). As previously shown, the development of hypertension in ANG II infused rats was prevented by losartan treatment. Blood and kidney samples were harvested, subjected to HPLC to separate Val5-ANG II (exogenous) from Ile5-ANG II (endogenous) and the fractions were measured by radioimmunoassay. In the Val5-ANG II infused rats treated with losartan, total plasma ANG II levels were elevated to a greater extent than in rats not treated with losartan (289 +/- 20 v 119 +/- 14 fmol/mL). However, losartan markedly decreased by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone. These results demonstrate that AT1 receptor blockade markedly reduces the intrarenal uptake of circulating ANG II that occurs in ANG II induced hypertension.
SynonymsAngiotensin II 5-valine TFA(58-49-1 free base)
Chemical Properties
Molecular Weight1146.18
FormulaC51H70F3N13O14
SmilesO=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)CC3=CNC=N3)=O)C(C)C)=O)CC4=CC=C(O)C=C4)=O)C(C)C)=O)CCCNC(N)=N.O=C(O)C(F)(F)F
Relative Density.no data available
SequenceH-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH
Sequence ShortDRVYVHPF
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Angiotensin ReceptorAngiotensin II 5-valine TFAAngiotensin II 5valine TFAAngiotensin II 5 valine TFA
Related Tags: buy Angiotensin II 5-valine TFA | purchase Angiotensin II 5-valine TFA | Angiotensin II 5-valine TFA cost | order Angiotensin II 5-valine TFA | Angiotensin II 5-valine TFA chemical structure | Angiotensin II 5-valine TFA in vivo | Angiotensin II 5-valine TFA formula | Angiotensin II 5-valine TFA molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.