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Angiotensin II 5-valine TFA

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Catalog No. TP1017L
Alias Angiotensin II 5-valine TFA(58-49-1 free base)

Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.

Angiotensin II 5-valine TFA
Other Forms of Angiotensin II 5-valine TFA:
Angiotensin II 5-valineTP101758-49-1
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Angiotensin II 5-valine TFA

🥰Excellent
Purity: 99.69%
Catalog No. TP1017LAlias Angiotensin II 5-valine TFA(58-49-1 free base)
Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$53In StockIn Stock
10 mg$68In StockIn Stock
50 mg$77In StockIn Stock
100 mg$116In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.69%
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COA HPLC MS

Product Introduction

Bioactivity
Description
Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.
In vivo
By day 12, systolic blood pressure (SBP) increased significantly in Val5-ANG II infused rats (197 +/- 7 mm Hg). As previously shown, the development of hypertension in ANG II infused rats was prevented by losartan treatment. Blood and kidney samples were harvested, subjected to HPLC to separate Val5-ANG II (exogenous) from Ile5-ANG II (endogenous) and the fractions were measured by radioimmunoassay. In the Val5-ANG II infused rats treated with losartan, total plasma ANG II levels were elevated to a greater extent than in rats not treated with losartan (289 +/- 20 v 119 +/- 14 fmol/mL). However, losartan markedly decreased by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone. These results demonstrate that AT1 receptor blockade markedly reduces the intrarenal uptake of circulating ANG II that occurs in ANG II induced hypertension.
SynonymsAngiotensin II 5-valine TFA(58-49-1 free base)
Chemical Properties
Molecular Weight1146.18
FormulaC51H70F3N13O14
SmilesO=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)CC3=CNC=N3)=O)C(C)C)=O)CC4=CC=C(O)C=C4)=O)C(C)C)=O)CCCNC(N)=N.O=C(O)C(F)(F)F
Relative Density.no data available
ColorWhite
AppearanceSolid
SequenceH-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH
Sequence ShortDRVYVHPF
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Angiotensin ReceptorAngiotensin II 5-valine TFAAngiotensin II 5valine TFAAngiotensin II 5 valine TFA
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