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Pravastatin sodium

Name: Pravastatin sodium
Brand: TargetMol
SKU: T0672
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0672Cas No. 81131-70-6

Alias CS-514 Sodium, CS-514 (sodium)

Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.

Pravastatin sodium

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Purity: 99.97%

Catalog No. T0672Alias CS-514 Sodium, CS-514 (sodium)Cas No. 81131-70-6

Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	In Stock	In Stock
25 mg	$55	In Stock	In Stock
50 mg	$66	In Stock	In Stock
100 mg	$101	In Stock	In Stock
200 mg	$130	In Stock	In Stock
500 mg	$215	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
Targets&IC50	HMG-CoA reductase:5.6 μM
In vitro	Pravastatin (30 mg/kg/day) reduced malnutrition-induced lesions by 34%. In female Wistar rats exposed to radiation, which presented with decreased CCN2 levels, Pravastatin (30 mg/kg/day) could restore muscle structure. A single dose of 40 mg of Pravastatin lowered cholesterol synthesis by 62% in monocytes from healthy individuals and by 47% in patients with hypercholesterolemia. Moreover, treatment with Pravastatin (40 mg/day for 8 weeks) in hypercholesterolemic patients increased LDL degradation by 57% while inhibiting cholesterol synthesis by 55%.
In vivo	In murine peritoneal macrophages (MPM), the J-774 A.1 macrophage-like cell line, and human monocyte-derived macrophages (HMDM), Pravastatin exhibits a dose-dependent inhibition of cholesterol synthesis. Upon LDL addition, concentrations of Pravastatin below 0.19 μg/mL enhance the esterification of cellular cholesterol, whereas levels below 100 μg/mL suppress esterification. At less than 0.5 mM, Pravastatin attenuates the Rho/ROCK pathway activity in human ileal and colonic transplants, reducing CCN2 mRNA levels. Pravastatin at concentrations less than 1 mM also induces the inhibition of CCN2 in primary human smooth muscle cells. In all cases, Pravastatin at less than 0.5 mM reduces the mRNA levels of type I collagen and fibronectin. Pravastatin facilitates vasodilation in aortic rings, achieving 62.8% endothelium-dependent relaxation at 10 μM after 8 minutes. Pravastatin-Na at 10 μM inhibits sterol synthesis with 50% greater efficacy than in peripheral blood mononuclear cells. In bovine aortic endothelial cells, Pravastatin at less than 10 μM stimulates NOS activity and NO release within 10 minutes, with L-arginine further enhancing NO production in response to Pravastatin.
Synonyms	CS-514 Sodium, CS-514 (sodium)

Chemical Properties

Molecular Weight	446.52
Formula	C₂₃H₃₅NaO₇
Cas No.	81131-70-6
Smiles	[C@H]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(=O)[O-])OC(=O)[C@@H](C)CC.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 44.7 mg/mL (100.11 mM), Sonication is recommended.

DMSO: 247.5 mg/mL (554.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2395 mL	11.1977 mL	22.3954 mL	111.9771 mL
5 mM	0.4479 mL	2.2395 mL	4.4791 mL	22.3954 mL
10 mM	0.2240 mL	1.1198 mL	2.2395 mL	11.1977 mL
20 mM	0.1120 mL	0.5599 mL	1.1198 mL	5.5989 mL
50 mM	0.0448 mL	0.2240 mL	0.4479 mL	2.2395 mL
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1198 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc