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AP1189 acetate

Name: AP1189 acetate
Brand: TargetMol
SKU: T9596
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9596Cas No. 959850-74-9

AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors.

AP1189 acetate

🥰Excellent

Purity: 99.95%

Catalog No. T9596Cas No. 959850-74-9

AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors.

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$83	In Stock
10 mg	$136	In Stock
25 mg	$247	In Stock
50 mg	$368	In Stock
100 mg	$523	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock

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Purity:99.95%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors.
In vitro	Added to macrophage cultures, AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes[1].
In vivo	Oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ～3-fold[1].

Chemical Properties

Molecular Weight	358.35
Formula	C₁₆H₁₈N₆O₄
Cas No.	959850-74-9
Smiles	O=[N+](C1=CC=CC=C1N2C(/C=C/C=N/NC(N)=N)=CC=C2)[O-].CC(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (139.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7906 mL	13.9528 mL	27.9057 mL	139.5284 mL
5 mM	0.5581 mL	2.7906 mL	5.5811 mL	27.9057 mL
10 mM	0.2791 mL	1.3953 mL	2.7906 mL	13.9528 mL
20 mM	0.1395 mL	0.6976 mL	1.3953 mL	6.9764 mL
50 mM	0.0558 mL	0.2791 mL	0.5581 mL	2.7906 mL
100 mM	0.0279 mL	0.1395 mL	0.2791 mL	1.3953 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc