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STING ligand-1

Name: STING ligand-1
Brand: TargetMol
SKU: T13906
Price: 197 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T13906 Copy Product Info

Purity: 98.83%

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STING ligand-1 is a lead stimulator of the STING pathway with an IC₅₀ of 68 nM for HAQ STING, STING ligand-1 I shows potential in research related to inflammation and immunology.

STING ligand-1

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Catalog No. T13906

STING ligand-1 is a lead stimulator of the STING pathway with an IC₅₀ of 68 nM for HAQ STING, STING ligand-1 I shows potential in research related to inflammation and immunology.

Cas No. 2365039-41-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$197	-	In Stock
5 mg	$496	-	In Stock
10 mg	$795	-	In Stock
25 mg	$1,490	-	In Stock
50 mg	$2,380	-	In Stock
1 mL x 10 mM (in DMSO)	$572	-	In Stock

In stock · Dispatch: USA[1-2d] Global[5-7d]

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.83%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS ORP CSFC FNMR

Product Introduction

Bioactivity

Description	STING ligand-1 is a lead stimulator of the STING pathway with an IC₅₀ of 68 nM for HAQ STING, STING ligand-1 I shows potential in research related to inflammation and immunology.
Targets&IC50	HAQ STING:68 nM
In vitro	STING ligand-1 exhibits good oral exposure, slow binding kinetics, and functional inhibition of STING-mediated cytokine release [1].

Chemical Properties

Molecular Weight	523.98
Formula	C₂₉H₂₇ClFNO₅
Cas No.	2365039-41-2
Smiles	C(C(O)=O)[C@@H]1[C@H](N(C(=O)C=2C1=CC=C(F)C2)C3=CC(Cl)=C(C(C)(C)C)C=C3)C=4C=C5C(=CC4)OCCO5
Relative Density.	1.322 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (152.68 mM), Sonication is recommeded.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9085 mL	9.5423 mL	19.0847 mL	95.4235 mL
5 mM	0.3817 mL	1.9085 mL	3.8169 mL	19.0847 mL
10 mM	0.1908 mL	0.9542 mL	1.9085 mL	9.5423 mL
20 mM	0.0954 mL	0.4771 mL	0.9542 mL	4.7712 mL
50 mM	0.0382 mL	0.1908 mL	0.3817 mL	1.9085 mL
100 mM	0.0191 mL	0.0954 mL	0.1908 mL	0.9542 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc