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Desacetylcinobufotalin

Name: Desacetylcinobufotalin
Brand: TargetMol
SKU: TN1572
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1572Cas No. 4099-30-3

Alias Deacetylcinobufotalin

Desacetylcinobufotalin is a natural product capable of inducing apoptosis in HepG2 cells by reducing Bax and Bcl-2 expression.

Desacetylcinobufotalin

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Purity: 99.88%

Catalog No. TN1572Alias DeacetylcinobufotalinCas No. 4099-30-3

Desacetylcinobufotalin is a natural product capable of inducing apoptosis in HepG2 cells by reducing Bax and Bcl-2 expression.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$123	-	In Stock
5 mg	$347	-	In Stock
10 mg	$515	-	In Stock
25 mg	$823	-	In Stock
50 mg	$1,090	-	In Stock
1 mL x 10 mM (in DMSO)	$379	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Desacetylcinobufotalin is a natural product capable of inducing apoptosis in HepG2 cells by reducing Bax and Bcl-2 expression.
In vitro	Desacetylcinobufotalin displayed a marked inhibitory effect on HepG2 cells, and the IC50 value is 0.0279μmol/ml. The expression of Bax was significantly increased, and the expression of Bcl-2 was markedly decreased, compared to the control[1].
Synonyms	Deacetylcinobufotalin

Chemical Properties

Molecular Weight	416.51
Formula	C₂₄H₃₂O₆
Cas No.	4099-30-3
Smiles	C[C@]12[C@]3([C@](O3)([C@H](O)[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(C)[C@](O)(CC5)C[C@@H](O)CC6)[H])[H]
Relative Density.	1.37 g/cm3 at 20℃

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (192.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4009 mL	12.0045 mL	24.0090 mL	120.0451 mL
5 mM	0.4802 mL	2.4009 mL	4.8018 mL	24.0090 mL
10 mM	0.2401 mL	1.2005 mL	2.4009 mL	12.0045 mL
20 mM	0.1200 mL	0.6002 mL	1.2005 mL	6.0023 mL
50 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4009 mL
100 mM	0.0240 mL	0.1200 mL	0.2401 mL	1.2005 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc