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Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $123 | - | In Stock | |
| 5 mg | $347 | - | In Stock | |
| 10 mg | $515 | - | In Stock | |
| 25 mg | $823 | - | In Stock | |
| 50 mg | $1,090 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $379 | - | In Stock |
| Description | Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines. |
| In vitro | The cytotoxicity of Desacetylcinobufotalin (DEBF) and apoptosis induced by DEBF was measured. Additionally the mechanism of Apoptosis induced by DEBF was studied through Western blot. The results show DEBF displayed the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279μmol/ml. The expression of Bax was significantly increased and the expression of Bcl-2 was markedly decreased, compared to the control[1] |
| Synonyms | Deacetylcinobufotalin |
| Molecular Weight | 416.51 |
| Formula | C24H32O6 |
| Cas No. | 4099-30-3 |
| Smiles | C[C@]12[C@]3([C@](O3)([C@H](O)[C@@H]1C=4C=CC(=O)OC4)[H])[C@]5([C@](CC2)([C@]6(C)[C@](O)(CC5)C[C@@H](O)CC6)[H])[H] |
| Relative Density. | 1.37 g/cm3 at 20℃ |
| Color | White |
| Appearance | Solid |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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