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TP-051
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Catalog No. T68535Cas No. 858097-86-6
Alias TP051
TP-051 is a potent and selective FFAR1 agonist exhibiting a Ki of 16 nM for human FFAR1, with demonstrated ability to enhance insulin secretion in rat insulinoma cells. TP-051 is widely used as a chemical probe for studying free-fatty-acid receptor-mediated pathways in type 2 diabetes and metabolic research.
TP-051
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Purity: 99.96%
Catalog No. T68535Alias TP051Cas No. 858097-86-6
TP-051 is a potent and selective FFAR1 agonist exhibiting a Ki of 16 nM for human FFAR1, with demonstrated ability to enhance insulin secretion in rat insulinoma cells. TP-051 is widely used as a chemical probe for studying free-fatty-acid receptor-mediated pathways in type 2 diabetes and metabolic research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $457 | - | In Stock | |
| 5 mg | $1,060 | - | In Stock | |
| 10 mg | $1,420 | - | In Stock | |
| 25 mg | $2,120 | - | In Stock | |
| 50 mg | $2,780 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.96%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TP-051 is a potent and selective FFAR1 agonist exhibiting a Ki of 16 nM for human FFAR1, with demonstrated ability to enhance insulin secretion in rat insulinoma cells. TP-051 is widely used as a chemical probe for studying free-fatty-acid receptor-mediated pathways in type 2 diabetes and metabolic research. |
| Targets&IC50 | FFAR1/GPR40 (human):16 nM (Ki) |
| In vitro | In the presence of 11 mM Vitis vinifera sugar, TP-051 (compound 31) acted on INS-1 cells for 2 hours at concentrations ranging from 0.01-10 μM, demonstrating a dose-dependent promotion of insulin secretion. When the concentration of this compound exceeded 0.1 μM, a statistically significant increase in insulin secretion was observed [1]. |
| Synonyms | TP051 |
| Molecular Weight | 526.62 |
| Formula | C29H31FO6S |
| Cas No. | 858097-86-6 |
| Smiles | O=C(O)CCC1=CC=C(OCC2=CC=CC(=C2)C3=C(C=C(OC4CCS(=O)(=O)CC4)C=C3C)C)C=C1F |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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