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Chelidonic acid

Name: Chelidonic acid
Brand: TargetMol
SKU: T5558
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5558Cas No. 99-32-1

Alias γ-Pyrone-2,6-dicarboxylic acid, Jervaic acid, Jerva acid

Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity.

Chelidonic acid

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Purity: 99.03%

Catalog No. T5558Alias γ-Pyrone-2,6-dicarboxylic acid, Jervaic acid, Jerva acidCas No. 99-32-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.03%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity.
Targets&IC50	Glutamate decarboxylase (GAD):1.2 μM (Ki)
In vivo	Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reactions induced by ovalbumin in mice by inhibiting caspase-1 activity[3].
Animal Research	female BALB/c mice was Maintained 6-week-old under pathogen-free conditions.?Sensitized mice on days 1, 5, and 14 by intraperitoneal ?injection of 100 μg OVA emulsified in 20 mg aluminum hydroxide and we challenged mice with 1.5 mg OVA.?Chelidonic acid was administrated orally before intranasal .?OVA challenge for 10 days.?Nasal symptoms were evaluated by counting the number of nasal rubs that occurred in the 10 min after OVA. provocation at 10 days after challenge.
Synonyms	γ-Pyrone-2,6-dicarboxylic acid, Jervaic acid, Jerva acid

Chemical Properties

Molecular Weight	184.10
Formula	C₇H₄O₆
Cas No.	99-32-1
Smiles	OC(=O)C1=CC(=O)C=C(O1)C(O)=O
Relative Density.	1.4880 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.00 mg/mL (21.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.00 mg/mL (5.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4318 mL	27.1592 mL	54.3183 mL	271.5915 mL
5 mM	1.0864 mL	5.4318 mL	10.8637 mL	54.3183 mL
10 mM	0.5432 mL	2.7159 mL	5.4318 mL	27.1592 mL
20 mM	0.2716 mL	1.3580 mL	2.7159 mL	13.5796 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc