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4-Chlorochalcone

Name: 4-Chlorochalcone
Brand: TargetMol
SKU: T205870
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T205870Cas No. 956-04-7

4-Chlorochalcone is a biologically active chalcone with potential inhibitory effects on human MAO-B and ROS/RNS production and is able to inhibit the growth of CAL51 cells.

4-Chlorochalcone

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Purity: 98.08%

Catalog No. T205870Cas No. 956-04-7

4-Chlorochalcone is a biologically active chalcone with potential inhibitory effects on human MAO-B and ROS/RNS production and is able to inhibit the growth of CAL51 cells.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	-	In Stock
500 mg	$55	-	In Stock
1 g	$83	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.08%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	4-Chlorochalcone is a biologically active chalcone with potential inhibitory effects on human MAO-B and ROS/RNS production and is able to inhibit the growth of CAL51 cells.
Targets&IC50	MAO-B:0.066 ± 0.0025 μM, AChE:1.25 ± 0.42 μM, MAO-A:9.10 ± 0.038 μM
In vitro	4-Chlorochalcone strongly inhibits MAO-A (IC₅₀ = 9.10 ± 0.038 μM) and MAO-B (IC₅₀ = 0.066 ± 0.0025 μM) in vitro, with slight MAO-B selectivity. 4-Chlorochalcone weakly inhibits AChE (IC₅₀ = 1.25 ± 0.42μM)[1].

Chemical Properties

Molecular Weight	242.7
Formula	C₁₅H₁₁ClO
Cas No.	956-04-7
Smiles	O=C(C=CC1=CC=C(Cl)C=C1)C=2C=CC=CC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 100 mg/mL (412.03 mM), Sonication and heating are recommended.

Ethanol: 1 mg/mL (4.12 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1203 mL	20.6016 mL	41.2031 mL	206.0157 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.8241 mL	4.1203 mL	8.2406 mL	41.2031 mL
10 mM	0.4120 mL	2.0602 mL	4.1203 mL	20.6016 mL
20 mM	0.2060 mL	1.0301 mL	2.0602 mL	10.3008 mL
50 mM	0.0824 mL	0.4120 mL	0.8241 mL	4.1203 mL
100 mM	0.0412 mL	0.2060 mL	0.4120 mL	2.0602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc