Shopping Cart

Your shopping cart is currently empty

IDO1-IN-1

Name: IDO1-IN-1
Brand: TargetMol
SKU: T20513
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T20513Cas No. 615-21-4

Alias IDO1-inhibitor-1, IDO1IN1, IDO1 inhibitor 1, 2-HzBTZ, 2 HzBTZ

IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

IDO1-IN-1

Copy Product Info

🥰Excellent

Purity: 99.36%

Catalog No. T20513Alias IDO1-inhibitor-1, IDO1IN1, IDO1 inhibitor 1, 2-HzBTZ, 2 HzBTZCas No. 615-21-4

IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.36%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

IDO1-IN-1 AI Summary

IDO1-IN-1 exhibits notable bioactivity across multiple domains. It demonstrates antitubercular activity against Mycobacterium tuberculosis H37Rv with a minimum inhibitory concentration (MIC) of 287.5 µg/mL after 7 days, as determined by the Resazurin microtiter assay. In addition, the compound shows significant growth inhibition across various human tumor cell lines, including breast, renal, lung, leukemia, central nervous system, melanoma, prostate, ovarian, and colon cancer cell lines, with a GI50 value of 100,000 nM in most cases. However, it exhibits stronger inhibitory activity in some leukemia and breast cancer cell lines such as MOLT-4, SR, and T-47D, where the GI50 values are slightly lower. Furthermore, IDO1-IN-1 acts as an inhibitor of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1), affecting both mouse and human IDO1 expressed in various cell lines and bacterial models by reducing L-tryptophan metabolism. It shows IC50 values ranging from 50,500 nM to 8,000 nM, with significant inhibition of IDO1 activity up to 91%. These findings suggest that IDO1-IN-1 holds potential as both an antitubercular and anti-cancer agent, and as an IDO1 inhibitor in various biological contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
Targets&IC50	IDO1:8 μM
Synonyms	IDO1-inhibitor-1, IDO1IN1, IDO1 inhibitor 1, 2-HzBTZ, 2 HzBTZ

Chemical Properties

Molecular Weight	165.22
Formula	C₇H₇N₃S
Cas No.	615-21-4
Smiles	NN=C1NC2=CC=CC=C2S1
Relative Density.	1.463 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (363.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0525 mL	30.2627 mL	60.5254 mL	302.6268 mL
5 mM	1.2105 mL	6.0525 mL	12.1051 mL	60.5254 mL
10 mM	0.6053 mL	3.0263 mL	6.0525 mL	30.2627 mL
20 mM	0.3026 mL	1.5131 mL	3.0263 mL	15.1313 mL
50 mM	0.1211 mL	0.6053 mL	1.2105 mL	6.0525 mL
100 mM	0.0605 mL	0.3026 mL	0.6053 mL	3.0263 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc