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Antitubercular agent-54 is an antitubercular compound with significant intracellular activity in macrophages (EC50 of 0.68 μM). It exhibits a minimum inhibitory concentration (MIC) of 0.31 μM against Mycobacterium tuberculosis (Mtb) H37Rv cultured with cholesterol. Antitubercular agent-54 is applicable in tuberculosis research.
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
| Description | Antitubercular agent-54 is an antitubercular compound with significant intracellular activity in macrophages (EC50 of 0.68 μM). It exhibits a minimum inhibitory concentration (MIC) of 0.31 μM against Mycobacterium tuberculosis (Mtb) H37Rv cultured with cholesterol. Antitubercular agent-54 is applicable in tuberculosis research. |
| In vitro | Antitubercular agent-54 (Compound P39) exhibits potent inhibitory activity against Mycobacterium tuberculosis (Mtb) under various metabolic states, with an EC50 of 0.68 μM for Mtb within macrophages and a MIC of 0.31 μM against Mtb H37Rv in cholesterol medium. At concentrations above 40 μM, Antitubercular agent-54 demonstrates no significant cytotoxicity to HEK293T and HepG2 cells, indicating a favorable safety profile. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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