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Anti-DC-SIGN Antibody (8R621)
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Catalog No. TMAY-00448
Alias DC-SIGN, CD209 molecule, CD209
Anti-DC-SIGN Antibody (8R621) is a Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody (8R621) can be used in WB,ELISA.
Anti-DC-SIGN Antibody (8R621)
Anti-DC-SIGN Antibody (8R621)
😃Good
Catalog No. TMAY-00448Alias DC-SIGN, CD209 molecule, CD209
Anti-DC-SIGN Antibody (8R621) is a Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody (8R621) can be used in WB,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: WB, ELISA Reactivity: Human |
| Alias | DC-SIGN, CD209 molecule, CD209 |
| Ig Type | Rabbit IgG |
| Clone | 8R621 |
| Reactivity | Human |
| Verified Activity | Anti-CD209 rabbit monoclonal antibody at 1:500 dilution. -Lane A: THP1 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:46 kDa. -Observed band size:46 kDa(We are unsure as to the identity of these extra bands.) |
| Application | WB,ELISA |
| Recommended Dose | WB: 1:500-1:1000; ELISA: 1:25000-1:50000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human DC-SIGN / CD209 (rh DC-SIGN / CD209; TMPY-00772; NP_066978.1; Lys62-Ala404). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human DC-SIGN / CD209 protein (TMPY-00772) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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